完整和肾上腺切除的 Zucker 大鼠棕色脂肪组织对下丘脑中心电刺激的反应。

Response of brown adipose tissue to electrical stimulation of hypothalamic centres in intact and adrenalectomized Zucker rats.

作者信息

Holt S J, Wheal H V, York D A

机构信息

Department of Human Nutrition, School of Biochemical and Physiological Sciences, Southampton University, U.K.

出版信息

Neurosci Lett. 1988 Jan 11;84(1):63-7. doi: 10.1016/0304-3940(88)90338-2.

DOI:10.1016/0304-3940(88)90338-2

PMID:3347372

Abstract

Electrical stimulation of the ventromedial nucleus of the hypothalamus (VMN) increased brown adipose tissue (BAT) temperature in lean and obese Zucker rats, whereas stimulation of the paraventricular nucleus (PVN) was without effect in either genotype, before or after adrenalectomy. The prolonged duration of the increase in BAT temperature in the obese (fa/fa) rat observed after VMN stimulation was normalized after adrenalectomy.

摘要

对下丘脑腹内侧核（VMN）进行电刺激可使瘦型和肥胖型 Zucker 大鼠的棕色脂肪组织（BAT）温度升高，而刺激室旁核（PVN）对两种基因型大鼠在肾上腺切除术前或术后均无影响。肾上腺切除术后，肥胖（fa/fa）大鼠在 VMN 刺激后观察到的 BAT 温度升高的持续时间延长恢复正常。