突发性感音神经性听力损失患者的甲状腺功能障碍分析
Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss.
作者信息
Zhu Yuhua, Bing Dan, Wang Dayong, Zhao Lidong, Yin Zifang, Zhang Qiujing, Guan Jing, Wang Qiuju
机构信息
Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, China.
Department of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Hainan, 572013, China.
出版信息
World J Otorhinolaryngol Head Neck Surg. 2020 Apr 29;7(1):1-8. doi: 10.1016/j.wjorl.2019.02.002. eCollection 2021 Jan.
BACKGROUND
Sudden sensorineural hearing loss (SSHL) refers to the sudden occurrence of unexplained sensorineural hearing loss. The present study showed that different systemic diseases had different influence on the occurrence and hearing outcome of SSHL. Thyroid hormone is one of the important factors for the development of fetal ear and auditory function. However, the distribution of thyroid dysfunction in SSHL patients and the effect of thyroid dysfunction on the occurrence and hearing outcome of SSHL has not been studied.
METHODS
In this study, a retrospective analysis had been done in 676 patients with SSHL. We had described the distribution of thyroid function in patients with SSHL in detail, and by the statistical method, analyzed the relationship between the hearing outcome and thyroid dysfunction, respectively.
RESULTS
In all patients, 24.41% (165/676) had abnormal thyroid function testing results. The onset age of SSHL in FT3 abnormal group (including low and high group) was younger than that in normal FT3 group. Recovery group had more patients with lower-than-normal T3 level as compared to non-recovery patients. Significant associations between T3 levels and hearing outcome were observed in the subgroup with longer time elapse between symptom onset and treatment (≥14 d).
CONCLUSION
The incidence of thyroid dysfunction in SSHL is significantly higher than in the general population. There was obvious relationship between T3 and FT3 item of thyroid dysfunction and the onset time and hearing outcome of SSHL, which indicated that T3 or FT3 indicator may be one of the affecting factors for the SSHL. Early screening and diagnosis of thyroid dysfunction, especial T3 level, may help to evaluate the prognosis in SSHL patients.
背景
突发性感音神经性听力损失（SSHL）指不明原因的突发性感音神经性听力损失。本研究表明，不同的全身性疾病对SSHL的发生及听力转归有不同影响。甲状腺激素是胎儿耳部及听觉功能发育的重要因素之一。然而，SSHL患者中甲状腺功能障碍的分布情况以及甲状腺功能障碍对SSHL发生及听力转归的影响尚未得到研究。
方法
本研究对676例SSHL患者进行了回顾性分析。我们详细描述了SSHL患者的甲状腺功能分布情况，并通过统计学方法分别分析了听力转归与甲状腺功能障碍之间的关系。
结果
在所有患者中，24.41%（165/676）甲状腺功能检测结果异常。FT3异常组（包括低值和高值组）SSHL的发病年龄低于FT3正常组。与未恢复患者相比，恢复组中T3水平低于正常的患者更多。在症状发作与治疗间隔时间较长（≥14天）的亚组中，观察到T3水平与听力转归之间存在显著关联。
结论
SSHL患者中甲状腺功能障碍的发生率显著高于普通人群。甲状腺功能障碍的T3和FT3指标与SSHL的发病时间及听力转归之间存在明显关系，这表明T3或FT3指标可能是影响SSHL的因素之一。早期筛查和诊断甲状腺功能障碍，尤其是T3水平，可能有助于评估SSHL患者的预后。
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