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单心室肺动脉环缩术:多紧才算足够紧以获得成功进展?

Univentricular Pulmonary Artery Banding: How Tight is Tight Enough for Successful Progress?

机构信息

Department of Pediatric Cardiovascular Surgery, Erzurum Regional Training and Research Hospital, Üniversite, Çat Yolu Cd, 25240, Yakutiye/Erzurum, Turkey.

Department of Pediatric Cardiology, Istanbul Saglik Bilimleri University Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.

出版信息

Pediatr Cardiol. 2021 Apr;42(4):840-848. doi: 10.1007/s00246-021-02548-7. Epub 2021 Jan 21.

DOI:10.1007/s00246-021-02548-7
PMID:33474612
Abstract

We investigated the effects of intraoperative parameters measured during pulmonary artery banding operations and pre-discharge parameters on the completion of Fontan procedures. Fifty consecutive patients with single-ventricle anomalies and unrestricted pulmonary blood flow who underwent a PAB operation in and were discharged from our hospital were retrospectively analyzed. Patients who underwent a Fontan operation, a Glenn shunt operation, or who were eligible for a Fontan procedure were defined as the "successful group." Patients who needed rebanding prior to a bidirectional Glenn shunt, patients who were not eligible for a Glenn shunt, and those underwent a takedown due to high pulmonary arterial pressure after implantation of a Glenn shunt were defined as the "failure-to-progress group." The successful group included 34 (68%) patients and the failure-to-progress group included 16 (32%) patients. The median age was 2 months (IQR 1-4 months). There was a statistically significant difference between the groups in terms of systolic pulmonary arterial pressure, mean pulmonary arterial pressure, and pulmonary arterial pressure/systemic arterial pressure after PAB (P = 0.01, 0.03, and 0.03, respectively). While the median gradient before discharge was 60 mm Hg (IQR 50-70 mm Hg) in the successful group, it was 47.5 mm Hg (IQR 45-63.7 mm Hg) in the failure-to-progress group (P = 0.05). Mortality was observed in one (2.9%) patient in the successful group and five (31.2%) patients in the failure-to-progress group (P = 0.04). Successful pulmonary arterial banding increases long-term survival. Adequate targets should be determined, efforts should be made to achieve these targets, and patients should be followed up closely in terms of rebanding when the targets are not reached.

摘要

我们研究了肺动脉环扎术中测量的术中参数和出院前参数对 Fontan 手术完成的影响。回顾性分析了 50 例因单心室畸形和无限制肺血流在我院接受肺动脉环扎术并出院的连续患者。接受 Fontan 手术、 Glenn 分流术或符合 Fontan 手术条件的患者定义为“成功组”。需要在双向 Glenn 分流术之前重新环扎的患者、不符合 Glenn 分流术条件的患者以及因 Glenn 分流术植入后肺动脉压升高而拆除的患者定义为“进展失败组”。成功组包括 34 例(68%)患者,进展失败组包括 16 例(32%)患者。中位年龄为 2 个月(IQR 1-4 个月)。两组在肺动脉环扎术后收缩压、平均肺动脉压和肺动脉压/体动脉压方面存在统计学差异(P=0.01、0.03 和 0.03)。成功组出院前中位梯度为 60mmHg(IQR 50-70mmHg),进展失败组为 47.5mmHg(IQR 45-63.7mmHg)(P=0.05)。成功组中有 1 例(2.9%)患者死亡,进展失败组中有 5 例(31.2%)患者死亡(P=0.04)。肺动脉环扎术成功可提高长期生存率。应确定适当的目标,努力实现这些目标,并在未达到目标时密切关注重新环扎。

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