Department of Pharmaceutics, Industrial Pharmacy, JSS College of Pharmacy, Sri Shivarathreeshwara Nagara, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru-570015, Karnataka, India.
Curr Drug Targets. 2021;22(10):1183-1195. doi: 10.2174/1389450122999210120204248.
Oral route of administration is widely accepted and desired because of its versatility, convenience, and, most importantly, patient compliance. Multiparticulate systems like granules and pellets are more advantageous when compared to single-unit dosage forms, as they are capable of distributing the drug more evenly in the gastrointestinal tract. The current paper focuses on pellets, the merits and demerits associated, various pelletization techniques, and their characterization. It also focuses on how pellets can be employed for drug delivery is controlled and sustained release formulations. It gives a complete emphasis on the drug and excipients that can be used in pellet formation, the marketed formulations, and the research pertaining to pellets.
口服给药途径因其多功能性、便利性以及最重要的是患者顺应性而被广泛接受和期望。与单剂量剂型相比，多颗粒系统（如颗粒和丸剂）具有更多优势，因为它们能够更均匀地在胃肠道中分布药物。本文主要关注丸剂，讨论其相关优缺点、各种丸剂制备技术及其特性。还重点介绍了丸剂如何用于控制药物传递和实现缓释制剂。本文全面介绍了可用于丸剂形成的药物和赋形剂、已上市的制剂以及与丸剂相关的研究。
