Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA.
Boston University School of Medicine, Boston, MA, USA.
Clin Otolaryngol. 2021 May;46(3):494-500. doi: 10.1111/coa.13719. Epub 2021 Feb 2.
Paediatric squamous cell carcinoma (SCC) of the larynx is rare; however, recent data seem to support the notion that this pathology is increasing in incidence. Although this has been the case for several decades, treatment algorithms for this patient population remain identical to those of adults.
The study consists of a systematic review and pooled analysis of oncologic outcomes in paediatric laryngeal SCC from a comprehensive literature search on OVID MEDLINE and EMBASE.
The average cohort age was 12.1 years. Nine (36%) had supraglottic primaries, and 16 (64%) had glottic primaries. Treatment included unimodal and combination therapy. No significant difference in survival was noted between surgically treated and non-surgically treated patients (5-year overall survival (OS): 68.2% vs 76.2%, P = .905), even when stratified for advanced-stage and supraglottic disease.
Paediatric patients with laryngeal HNSCC may have different presentations and responses to therapy than their adult counterparts.
小儿喉鳞状细胞癌（SCC）较为罕见；然而，最近的数据似乎表明，这种疾病的发病率正在上升。尽管几十年来一直如此，但针对这一患者群体的治疗方案仍与成人相同。
本研究通过对 OVID MEDLINE 和 EMBASE 的全面文献检索，对小儿喉 SCC 的肿瘤学结果进行了系统评价和汇总分析。
平均队列年龄为 12.1 岁。9 例（36%）为声门上型原发性肿瘤，16 例（64%）为声带型原发性肿瘤。治疗包括单一模式和联合治疗。手术治疗和非手术治疗患者的生存无显著差异（5 年总生存率（OS）：68.2% vs 76.2%，P=0.905），即使按晚期和声门上疾病分层也是如此。
与成人相比，患有喉头颈部 SCC 的小儿患者的临床表现和对治疗的反应可能有所不同。
