Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
J Phys Chem Lett. 2021 Jan 28;12(3):1110-1115. doi: 10.1021/acs.jpclett.0c03313. Epub 2021 Jan 21.
Quinone methides (QMs) are very important intermediates in chemistry. These species are most often generated in situ with metal oxidants and transition metal complexes. Here, tip-enhanced Raman spectroscopy (TERS) has been implemented to investigate the in situ oxidative generation of a QM species from alkylphenols facilitated by a transition metal complex. Using TERS, the metal oxidant-mediated transformation of a phenol species has been observed. The subsequent oxidative addition reaction of QM has also been identified based on distinct vibrational features, which have been assigned based on density functional theory (DFT). This study may establish TERS as a chemical detection tool for various QM-mediated reactions.
醌甲基（QM）是化学中非常重要的中间体。这些物质通常在原位通过金属氧化剂和过渡金属配合物生成。在此，采用尖端增强拉曼光谱（TERS）研究了过渡金属配合物促进的烷基酚的 QM 物种的原位氧化生成。使用 TERS，观察到了金属氧化剂介导的酚类物质的转化。基于密度泛函理论（DFT），根据独特的振动特征，还确定了随后的 QM 氧化加成反应。本研究可能将 TERS 确立为用于各种 QM 介导的反应的化学检测工具。
