Steve Hicks School of Social Work, The University of Texas at Austin, Austin, TX, USA.
Central Texas Poison Center, Temple, TX, USA.
Clin Toxicol (Phila). 2021 Sep;59(9):822-831. doi: 10.1080/15563650.2020.1869756. Epub 2021 Jan 21.
CONTEXT/OBJECTIVES: A significant proportion of individuals aged 50+ in the U.S. use cannabis for medical or recreational purposes, sometimes with adverse effects. Given differences in cannabis use among men and women, we examined sex differences in (1) cannabis forms used, (2) exposure reasons, and (3) medical outcomes in older-adult poison control center (PCC) cases.
Data came from the American Association of Poison Control Centers' National Poison Data System, 2009-2019. We focused on the 3633 cases aged 50+ in which plant and other non-synthetic cannabinoid cannabis forms were the only or primary substance. Logistic regression was used to examine associations of sex with cannabis forms. Multinomial logistic regression models were fit to examine associations of sex with exposure reasons (therapeutic errors/adverse reactions, intentional misuse/abuse, other) and medical outcomes (no-to-minimal, moderate, or major effects).
Females constituted 57.4% of cases. In multivariable analyses, female cases had 1.20 (95% CI = 1.01-1.43) greater odds of involving cannabis forms other than plant forms and 1.93 greater odds (95% CI = 1.66-2.24) of therapeutic errors/adverse effects compared to intentional misuse/abuse. Older age and occurrence in recreational-cannabis-legal states were positively associated with other cannabis forms. Older age, recreational and/or medical cannabis-legal states, CBD, pharmaceuticals, concentrated extracts, and chronic exposure were associated with higher odds of therapeutic errors/adverse effects. Sex was not significantly associated with medical outcomes.
Female cases compose a large share of PCC cases aged 50+ and are associated with higher odds of involving cannabis forms other than plants and therapeutic errors/adverse reactions compared to intentional misuse/abuse.
背景/目的：美国有相当一部分 50 岁以上的人出于医疗或娱乐目的使用大麻，有时会产生不良反应。鉴于男性和女性的大麻使用存在差异，我们研究了老年（50 岁以上）中毒控制中心（PCC）病例中（1）使用的大麻形式、（2）暴露原因和（3）医疗结果的性别差异。
数据来自美国毒物控制中心协会的国家毒物数据系统，时间为 2009 年至 2019 年。我们重点关注了 3633 例仅使用植物和其他非合成大麻素大麻形式或主要使用这些物质的 50 岁以上病例。采用逻辑回归检验性别与大麻形式之间的关联。采用多项逻辑回归模型检验性别与暴露原因（治疗错误/不良反应、故意误用/滥用、其他）和医疗结果（无到轻微、中度或重度影响）之间的关联。
女性病例占 57.4%。在多变量分析中，与故意误用/滥用相比，女性病例涉及植物以外的大麻形式的可能性高 1.20 倍（95%CI=1.01-1.43），治疗错误/不良反应的可能性高 1.93 倍（95%CI=1.66-2.24）。年龄较大和发生在娱乐大麻合法州与其他大麻形式有关。年龄较大、娱乐和/或医疗大麻合法州、CBD、药物、浓缩提取物和慢性暴露与治疗错误/不良反应的可能性较高有关。性别与医疗结果无显著关联。
50 岁以上 PCC 病例中女性病例占很大比例，与涉及植物以外的大麻形式和治疗错误/不良反应的可能性较高有关，而不是与故意误用/滥用有关。
