• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

The impact of voxelotor treatment on leg ulcers in patients with sickle cell disease.

作者信息

Minniti Caterina P, Knight-Madden Jennifer, Tonda Margaret, Gray Sarah, Lehrer-Graiwer Joshua, Biemond Bart J

机构信息

Department of Hematology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.

Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Mona, Kingston, Jamaica.

出版信息

Am J Hematol. 2021 Apr 1;96(4):E126-E128. doi: 10.1002/ajh.26101. Epub 2021 Feb 19.

DOI:10.1002/ajh.26101
PMID:33476432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7986764/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0a/7986764/dbab179e6568/AJH-96-E126-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0a/7986764/dbab179e6568/AJH-96-E126-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0a/7986764/dbab179e6568/AJH-96-E126-g001.jpg

相似文献

1
The impact of voxelotor treatment on leg ulcers in patients with sickle cell disease.羟基脲治疗对镰状细胞病患者腿部溃疡的影响。
Am J Hematol. 2021 Apr 1;96(4):E126-E128. doi: 10.1002/ajh.26101. Epub 2021 Feb 19.
2
Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data.伏洛托珠单抗(GBT440),一种首创的血红蛋白氧亲和力调节剂,拥有令人鼓舞且可靠的临床前和临床数据。
Am J Hematol. 2018 Mar;93(3):326-329. doi: 10.1002/ajh.25042.
3
Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial.伏打诺特治疗青少年和成年镰状细胞病患者(HOPE)的研究:一项国际、随机、双盲、安慰剂对照的 3 期临床试验的长期随访结果。
Lancet Haematol. 2021 May;8(5):e323-e333. doi: 10.1016/S2352-3026(21)00059-4. Epub 2021 Apr 7.
4
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease.一项针对镰状细胞病患者的 voxotor 的 3 期随机试验。
N Engl J Med. 2019 Aug 8;381(6):509-519. doi: 10.1056/NEJMoa1903212. Epub 2019 Jun 14.
5
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease.一项评估 voxeloTOR 在镰状细胞病患者中的 1/2 期递增剂量和开放标签扩展研究。
Blood. 2019 Apr 25;133(17):1865-1875. doi: 10.1182/blood-2018-08-868893. Epub 2019 Jan 17.
6
How do we monitor hemoglobin S in patients who undergo red blood cell exchange and take voxelotor?我们如何监测接受红细胞置换并服用伏洛妥珠单抗的患者的血红蛋白S?
Transfusion. 2021 Jun;61(6):1680-1683. doi: 10.1111/trf.16405. Epub 2021 Apr 20.
7
Sickle cell anemia and COVID-19: Use of voxelotor to avoid transfusion.镰状细胞贫血与2019冠状病毒病:使用伐昔洛韦避免输血。
Transfusion. 2020 Dec;60(12):3066-3067. doi: 10.1111/trf.16068. Epub 2020 Sep 24.
8
Haemoglobin response to senicapoc in patients with sickle cell disease: a re-analysis of the Phase III trial.镰状细胞病患者对司尼卡波的血红蛋白反应:III期试验的重新分析
Br J Haematol. 2021 Mar;192(5):e129-e132. doi: 10.1111/bjh.17345. Epub 2021 Feb 1.
9
Voxelotor for the Treatment of Sickle Cell Disease.伏打络索治疗镰状细胞病。
Nurs Womens Health. 2020 Jun;24(3):233-237. doi: 10.1016/j.nwh.2020.03.003. Epub 2020 May 6.
10
Voxelotor (GBT440) produces interference in measurements of hemoglobin S.伏洛托(GBT440)会干扰血红蛋白S的测量。
Clin Chim Acta. 2018 Jul;482:57-59. doi: 10.1016/j.cca.2018.03.032. Epub 2018 Mar 27.

引用本文的文献

1
A retrospective research of adverse event reporting system events for voxelotor based on the FAERS database.基于FAERS数据库对基于voxelotor的不良事件报告系统事件进行的回顾性研究。
BMC Pharmacol Toxicol. 2025 Apr 3;26(1):74. doi: 10.1186/s40360-025-00915-1.
2
Selecting patients with sickle cell disease for gene addition or gene editing-based therapeutic approaches: Report on behalf of a joint EHA Specialized Working Group and EBMT Hemoglobinopathies Working Party consensus conference.为基于基因添加或基因编辑的治疗方法选择镰状细胞病患者:代表欧洲血液学协会(EHA)专门工作组和欧洲血液与骨髓移植协会(EBMT)血红蛋白病工作组联合共识会议撰写的报告
Hemasphere. 2025 Mar 13;9(3):e70089. doi: 10.1002/hem3.70089. eCollection 2025 Mar.
3

本文引用的文献

1
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease.一项针对镰状细胞病患者的 voxotor 的 3 期随机试验。
N Engl J Med. 2019 Aug 8;381(6):509-519. doi: 10.1056/NEJMoa1903212. Epub 2019 Jun 14.
2
The psychosocial impact of leg ulcers in patients with sickle cell disease: I don't want them to know my little secret.镰状细胞病患者腿部溃疡的心理社会影响:我不想让他们知道我的小秘密。
PLoS One. 2017 Oct 18;12(10):e0186270. doi: 10.1371/journal.pone.0186270. eCollection 2017.
3
Intravascular hemolysis and the pathophysiology of sickle cell disease.
Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.
羟基脲对成年镰状细胞病患者脑灌注、脑氧代谢及心脏应激的影响。
Am J Hematol. 2025 Jan;100(1):78-84. doi: 10.1002/ajh.27522. Epub 2024 Nov 20.
4
Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report.高压氧成功治疗镰状细胞性腿部溃疡:一例报告
Front Med (Lausanne). 2023 Jun 15;10:1171971. doi: 10.3389/fmed.2023.1171971. eCollection 2023.
5
Practical Guidance for the Use of Voxelotor in the Management of Sickle Cell Disease.使用伏洛昔托治疗镰状细胞病的实用指南。
J Blood Med. 2022 Nov 29;13:739-745. doi: 10.2147/JBM.S362222. eCollection 2022.
6
Clinical Vignettes Part I.临床病例简述(一)
Hematol Oncol Clin North Am. 2022 Dec;36(6):1187-1199. doi: 10.1016/j.hoc.2022.08.001.
7
Recent Advances in Sickle-Cell Disease Therapies: A Review of Voxelotor, Crizanlizumab, and L-glutamine.镰状细胞病治疗的最新进展:对伏洛托珠单抗、克瑞莎珠单抗和L-谷氨酰胺的综述
Pharmacy (Basel). 2022 Sep 26;10(5):123. doi: 10.3390/pharmacy10050123.
血管内溶血与镰状细胞病的病理生理学
J Clin Invest. 2017 Mar 1;127(3):750-760. doi: 10.1172/JCI89741.
4
Critical Reviews: How we treat sickle cell patients with leg ulcers.Critical Reviews:我们如何治疗患有腿部溃疡的镰状细胞病患者。
Am J Hematol. 2016 Jan;91(1):22-30. doi: 10.1002/ajh.24134. Epub 2015 Aug 14.
5
Interventions for treating leg ulcers in people with sickle cell disease.镰状细胞病患者腿部溃疡的治疗干预措施。
Cochrane Database Syst Rev. 2014 Dec 8;2014(12):CD008394. doi: 10.1002/14651858.CD008394.pub3.
6
Leg ulcers in sickle cell disease: current patterns and practices.镰状细胞病中的腿部溃疡:当前模式与实践
Hemoglobin. 2013;37(4):325-32. doi: 10.3109/03630269.2013.789968. Epub 2013 Apr 19.
7
Laboratory and echocardiography markers in sickle cell patients with leg ulcers.镰状细胞病患者下肢溃疡的实验室和超声心动图标志物。
Am J Hematol. 2011 Aug;86(8):705-8. doi: 10.1002/ajh.22065. Epub 2011 May 31.
8
Leg ulcers in sickle cell disease.镰状细胞病中的腿部溃疡。
Am J Hematol. 2010 Oct;85(10):831-3. doi: 10.1002/ajh.21838.
9
Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients.镰状细胞贫血的结局:对1056例患者的40年观察研究
Medicine (Baltimore). 2005 Nov;84(6):363-376. doi: 10.1097/01.md.0000189089.45003.52.
10
Leg ulcers in patients with sickle cell disease.镰状细胞病患者的腿部溃疡
Blood. 1989 Sep;74(4):1403-8.