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深部浸润型子宫内膜异位症手术后排尿功能障碍的预测因素

Predictive Factors for Voiding Dysfunction after Surgery for Deep Infiltrating Endometriosis.

作者信息

Imboden Sara, Bollinger Yaelle, Härmä Kirsi, Knabben Laura, Fluri Mihaela, Nirgianakis Konstantinos, Mohr Stefan, Kuhn Annette, Mueller Michael D

机构信息

Department of Gynecology and Obstetrics, University Hospital of Bern and University of Bern, Bern, Switzerland (all authors)..

Department of Gynecology and Obstetrics, University Hospital of Bern and University of Bern, Bern, Switzerland (all authors).

出版信息

J Minim Invasive Gynecol. 2021 Aug;28(8):1544-1551. doi: 10.1016/j.jmig.2021.01.009. Epub 2021 Jan 18.

DOI:10.1016/j.jmig.2021.01.009
PMID:33476749
Abstract

STUDY OBJECTIVE

To evaluate the prognostic value of pre- and perioperative factors for voiding dysfunction after surgery for deep infiltrating endometriosis (DIE).

DESIGN

Single-center retrospective cohort study.

SETTING

University hospital.

PATIENTS

A total of 198 women with DIE in the posterior compartment who underwent surgery and a postoperative bladder scan.

INTERVENTIONS

Surgical resection of the DIE nodule from the dorsal compartment.

MEASUREMENTS AND MAIN RESULTS

After surgery, 41% of the patients initially experienced voiding dysfunction (defined as >100 mL postvoid residual urine volume at second bladder scan). The number decreased to 11% by the time of hospital discharge. Among those with a need for self-catheterization after discharge (n = 17), voiding dysfunction lasted for a median of 41 days before a return to normal bladder function, with a residual urine volume of <100 mL. The preoperative presence of DIE nodules in the ENZIAN compartment B was associated with postoperative voiding dysfunction (p = .001). The hazard ratio for elevated residual urine volume was highest when the disease stage was B3 (hazard ratio 6.43; CI, 2.3-18.2; p <.001), describing a nodule diameter of >3 cm in lateral distension. Receiver operating characteristic curve analyses showed that a first residual urine volume >220 mL has a good predictive value for the risk of intermittent self-catheterization (area under the receiver operating characteristic curve 0.893; p <.001).

CONCLUSION

Postoperative voiding dysfunction is frequent; of note, in most cases the problem is temporary. When DIE with an ENZIAN classification B is noted intraoperatively and, most of all, when the diameter of the lesion is >3 cm, a higher risk of postoperative voiding dysfunction is to be expected.

摘要

研究目的

评估术前和围手术期因素对深部浸润型子宫内膜异位症(DIE)手术后排尿功能障碍的预后价值。

设计

单中心回顾性队列研究。

地点

大学医院。

患者

共有198例后盆腔深部浸润型子宫内膜异位症患者接受了手术及术后膀胱扫描。

干预措施

从背侧盆腔手术切除深部浸润型子宫内膜异位症结节。

测量指标及主要结果

术后,41%的患者最初出现排尿功能障碍(定义为第二次膀胱扫描时残余尿量>100 mL)。到出院时,这一比例降至11%。在出院后需要自行导尿的患者(n = 17)中,排尿功能障碍在恢复正常膀胱功能前持续的中位时间为41天,残余尿量<100 mL。术前ENZIAN B区存在深部浸润型子宫内膜异位症结节与术后排尿功能障碍相关(p = 0.001)。当疾病分期为B3时,残余尿量升高的风险比最高(风险比6.43;CI,2.3 - 18.2;p < 0.001),描述为侧方扩张时结节直径>3 cm。受试者工作特征曲线分析表明,首次残余尿量>220 mL对间歇性自行导尿风险具有良好的预测价值(受试者工作特征曲线下面积0.893;p < 0.001)。

结论

术后排尿功能障碍很常见;值得注意的是,在大多数情况下,问题是暂时的。术中发现ENZIAN分类为B的深部浸润型子宫内膜异位症时,尤其是当病变直径>3 cm时,术后排尿功能障碍的风险较高。

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