Horne Justine R
Centre nutrition, santé et société (NUTRISS) - Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Quebec City, Québec, Canada,
Lifestyle Genom. 2021;14(2):43-48. doi: 10.1159/000512544. Epub 2021 Jan 21.
The ultimate goal of researching nutrigenetic interactions is to be able to provide individuals with genetically-tailored nutrition advice (when evidence is sufficient) in an effort to optimize health outcomes. Accordingly, original research often discusses the potential for the results to inform genetically-tailored nutrition advice. Despite this, many studies do not report their methods, results, and discussion in a manner that is conducive to knowledge translation. With several consumer nutritional genomics companies now offering genetic testing for personalized nutrition, proper reporting of nutritional genomics research for knowledge translation is of vital importance. Common reporting errors relate to SNP and genotype reporting, results lacking detail, consideration of linkage disequilibrium, mechanisms of action/functional SNPs, details of dietary intake, and sample reporting. Because of this, knowledge translation professionals may be unable or challenged in their attempt to use the findings from such research to inform clinical practice in nutritional genomics and personalized nutrition. The present article provides an overview of the issues at hand. It further pre-sents a checklist as well as table and figure templates for researchers to use when reporting the results of original research in nutritional genomics to inform knowledge translation.
营养基因相互作用研究的最终目标是，在证据充分时能够为个体提供基于基因定制的营养建议，以优化健康结果。因此，原创研究常常会探讨研究结果用于基因定制营养建议的可能性。尽管如此，许多研究在报告其方法、结果和讨论时，并未采用有利于知识转化的方式。现在有几家消费者营养基因组学公司提供个性化营养基因检测服务，因此，为了实现知识转化而正确报告营养基因组学研究至关重要。常见的报告错误涉及单核苷酸多态性（SNP）和基因型报告、结果缺乏细节、连锁不平衡的考虑、作用机制/功能性SNP、饮食摄入细节以及样本报告。正因为如此，知识转化专业人员在尝试利用此类研究结果为营养基因组学和个性化营养的临床实践提供信息时，可能会遇到困难或无法做到。本文概述了当前存在的问题。它还为研究人员在报告营养基因组学原创研究结果以促进知识转化时提供了一份清单以及表格和图表模板。
