Atherectomy plus drug-coated balloon versus drug-coated balloon only for treatment of femoropopliteal artery lesions: A systematic review and meta-analysis.

OBJECTIVES

To compare the safety and efficiency of atherectomy plus drug-coated balloon with drug-coated balloon only for the treatment of femoropopliteal artery lesions.

METHODS

This systematic review and meta-analysis was performed and reported following the requirement of the PRISMA. EMBASE, MEDLINE, and Cochrane library were queried from January 2000 to June 2020 to identify eligible literature. The modified Downs and Black checklist was used to assess the quality of included studies. Outcome measures included bail-out stenting, distal embolization, perforation, hematoma, primary patency at 12 months, target lesion revascularization at 12 months, leg amputation at 12 months, and mortality at 12 months. We used DerSimonian and Laird random-effects model to pool the dichotomous data on risk ratio (RR) with 95% confidence intervals (CIs) from each study to obtain an overall estimate for major outcomes. Subgroup analysis and sensitivity analyses were conducted.

RESULTS

Six studies (two randomized controlled trials and four retrospective cohort studies) with 470 patients were included. Atherectomy plus drug-coated balloon group was associated with lower rates of bail-out stenting (RR: 0.49, 95%CI: 0.34-0.71,  < 0.001). There was no significant difference between two groups in terms of distal embolization (RR: 2.06, 95%CI: 0.51-8.38,  = 0.31), perforation (RR: 2.04, 95%CI: 0.43-9.71,  = 0.37), hematoma (RR: 1.75, 95%CI: 0.43-7.09,  = 0.43), primary patency at 12 months (1.09, 95%CI: 0.98-1.21,  = 0.12), target lesion revascularization at 12 months (RR: 0.68, 95%CI: 0.41-1.14,  = 0.15), leg amputations at 12 months (RR: 0.54, 95%CI: 0.13-2.23,  = 0.39), mortality at 12 months (RR: 2.18, 95%CI: 0.71-6.64,  = 0.17). Sensitivity analysis had no effect on our findings.

CONCLUSIONS

The combination of atherectomy and drug-coated balloon was safe and effective in the treatment of femoropopliteal artery lesions, with lower incidence of bail-out stenting compared with drug-coated balloon only.