Ashrafizadeh Milad, Rafiei Hossein, Mohammadinejad Reza, Farkhondeh Tahereh, Samarghandian Saeed
Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, Istanbul, 34956, Turkey.
Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, Turkey.
Cancer Cell Int. 2021 Jan 21;21(1):66. doi: 10.1186/s12935-021-01773-7.
Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increase in the survival time of patients with GC. Multiple studies have revealed that Wnt, Nrf2, MAPK, and PI3K/Akt signaling pathways are involved in GC invasion. Besides, long non-coding RNAs and microRNAs function as upstream mediators in GC malignancy. GC cells have acquired resistance to currently applied anti-tumor drugs. Besides, combination therapy is associated with higher anti-tumor activity. Resveratrol (Res) is a non-flavonoid polyphenol with high anti-tumor activity used in treatment of various cancers. A number of studies have demonstrated the potential of Res in regulation of molecular pathways involved in cancer malignancy. At the present review, we show that Res targets a variety of signaling pathways to induce apoptotic cell death and simultaneously, to inhibit the migration and metastasis of GC cells.
胃癌（GC）是最常见的恶性肿瘤之一。尽管诊断工具和抗肿瘤药物的应用有了很大发展，但我们并未看到胃癌患者的生存时间有显著增加。多项研究表明，Wnt、Nrf2、MAPK和PI3K/Akt信号通路参与胃癌侵袭。此外，长链非编码RNA和微小RNA在胃癌恶性肿瘤中作为上游介质发挥作用。胃癌细胞已对目前应用的抗肿瘤药物产生耐药性。此外，联合治疗具有更高的抗肿瘤活性。白藜芦醇（Res）是一种具有高抗肿瘤活性的非黄酮类多酚，用于治疗各种癌症。许多研究已经证明Res在调节参与癌症恶性肿瘤的分子途径方面的潜力。在本综述中，我们表明Res靶向多种信号通路以诱导凋亡性细胞死亡，同时抑制胃癌细胞的迁移和转移。
