School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Drug Des Devel Ther. 2024 Jul 25;18:3233-3253. doi: 10.2147/DDDT.S466470. eCollection 2024.
Gastric cancer (GC) is a prevalent gastrointestinal tumor characterized by high mortality and recurrence rates. Current treatments often have limitations, prompting researchers to explore novel anti-tumor substances and develop new drugs. Flavonoids, natural compounds with diverse biological activities, are gaining increasing attention in this regard. We searched from PubMed, Web of Science, SpringerLink and other databases to find the relevant literature in the last two decades. Using "gastric cancer", "stomach cancers", "flavonoid", "bioflavonoid", "2-Phenyl-Chromene" as keywords, were searched, then analyzed and summarized the mechanism of flavonoids in the treatment of GC. It was revealed that the anti-tumor mechanism of flavonoids involves inhibiting tumor growth, proliferation, invasion, and metastasis, as well as inducing cell death through various processes such as apoptosis, autophagy, ferroptosis, and pyroptosis. Additionally, combining flavonoids with other chemotherapeutic agents like 5-FU and platinum compounds can potentially reduce chemoresistance. Flavonoids have also demonstrated enhanced biological activity when used in combination with other natural products. Consequently, this review proposes innovative perspectives for the development of flavonoids as new anti-GC agents.
胃癌（GC）是一种常见的胃肠道肿瘤，其死亡率和复发率较高。目前的治疗方法往往存在局限性，促使研究人员探索新型抗肿瘤物质并开发新的药物。类黄酮作为具有多种生物活性的天然化合物，在这方面受到越来越多的关注。我们从 PubMed、Web of Science、SpringerLink 等数据库中搜索了过去二十年的相关文献。使用“胃癌”“胃肿瘤”“类黄酮”“生物类黄酮”“2-苯基色烯”作为关键词进行搜索，然后对类黄酮治疗 GC 的机制进行分析和总结。结果表明，类黄酮的抗肿瘤机制涉及通过多种过程如细胞凋亡、自噬、铁死亡和细胞焦亡来抑制肿瘤生长、增殖、侵袭和转移，以及诱导细胞死亡。此外，将类黄酮与其他化疗药物如 5-FU 和铂类化合物联合使用可能会降低化疗耐药性。类黄酮与其他天然产物联合使用时也表现出增强的生物活性。因此，本综述为开发类黄酮作为新型抗 GC 药物提出了创新观点。
