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真性红细胞增多症患者在接受椎管内麻醉后发生脊髓蛛网膜下腔血肿。

Spinal subarachnoid haematoma after neuraxial anaesthesia in a patient with polycythaemia vera.

作者信息

Martins T, Montenegro L, Silva A, Reis H, Pereira E, Lucas P

机构信息

Department of Anaesthesia Hospital Garcia de Orta Almada Portugal.

出版信息

Anaesth Rep. 2021 Jan 12;9(1):8-11. doi: 10.1002/anr3.12093. eCollection 2021 Jan-Jun.

Abstract

Polycythaemia vera is a common haematological proliferative disorder. It is characterised by uncontrolled red cell production with ensuing peri-operative vaso-occlusive and haemorrhagic complications. Spinal haematoma after neuraxial anaesthesia is rare; most cases are associated with technical difficulties or bleeding disorders. Current consensus opinion suggests that neuraxial anaesthesia in patients with polycythaemia vera is safe due to a lower risk of thrombotic events and hypoxaemia compared with general anaesthesia. We report a case of a spinal subarachnoid haematoma after uneventful neuraxial anaesthesia in a patient with optimised polycythaemia vera. Despite an emergent laminectomy, the patient developed permanent motor deficits. This report highlights that although neuraxial anaesthesia is recommended by many authors, patients with polycythaemia vera can paradoxically have an increased haemorrhagic risk from platelet dysfunction and acquired von Willebrand disease. Clinicians proceeding with surgery under neuraxial anaesthesia should appreciate these risks even in patients with normal or apparently elevated thrombotic states. This case also demonstrates that traditional coagulation tests may need to be complemented by pre-operative platelet function tests and screening for von Willebrand disease. Finally, the importance of the patient participation in the choice of the anaesthesia technique cannot be understated, with specific attention paid to this frequently unrecognised risk.

摘要

真性红细胞增多症是一种常见的血液系统增殖性疾病。其特征为红细胞生成不受控制,随之而来的是围手术期血管阻塞和出血并发症。神经轴索麻醉后发生脊髓血肿较为罕见;大多数病例与技术困难或出血性疾病有关。目前的共识意见认为,与全身麻醉相比,真性红细胞增多症患者接受神经轴索麻醉是安全的,因为血栓形成事件和低氧血症的风险较低。我们报告一例真性红细胞增多症病情得到优化的患者,在神经轴索麻醉过程顺利后发生脊髓蛛网膜下腔血肿的病例。尽管紧急进行了椎板切除术,但患者仍出现了永久性运动功能障碍。本报告强调,尽管许多作者推荐神经轴索麻醉,但真性红细胞增多症患者可能因血小板功能障碍和获得性血管性血友病而反常地增加出血风险。即使在血栓形成状态正常或明显升高的患者中,接受神经轴索麻醉进行手术的临床医生也应认识到这些风险。该病例还表明,传统凝血试验可能需要术前血小板功能试验和血管性血友病筛查加以补充。最后,患者参与麻醉技术选择的重要性不可低估,应特别关注这种经常未被认识到的风险。

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