Post Graduate Program in Health Sciences, Maringá State University, Avenida Colombo, 5790, Maringa, Parana, 87020-900, Brazil.
Nursing, Maringá State University, Maringa, Parana, Brazil.
Osteoporos Int. 2021 Jul;32(7):1351-1358. doi: 10.1007/s00198-021-05851-4. Epub 2021 Jan 21.
Although lactation is associated with transient bone loss and body weight changes, the unchanged TBS could highlight a limited effectiveness in detecting dynamic bone properties in the first year postpartum.
To evaluate trabecular bone score (TBS) and bone mineral density (BMD) in postpartum women.
This was a 12-month prospective cohort study with 40 lactating postpartum women and 44 non-pregnant women. The inclusion criteria were as follows: aged between 18 and 35 years old, an uncomplicated term (≥37 weeks) pregnancy with a single fetus, and no intention of becoming pregnant within 12 months. BMD measurements, including spine, hip, forearm and whole body, were performed by DXA at four different time points after delivery: (1) 1st month, (2) 3rd-4th month, (3) 6th-9th month, and (4) ≥ 12th month postpartum.
BMD measurements showed a statistically significant decrease at spine (1.134 vs. 1.088 g/cm, p < 0.01), femoral neck (0.988 vs. 0.946 g/cm, p < 0.01), total femur (0.971 vs. 0.933 g/cm, p < 0.01), and whole body (1.132 vs. 1.119 g/cm, p = 0.03) at the 2nd assessment (peak of lactation). There was early spinal recovery after the 3rd assessment with complete recovery in all skeletal sites. Although it has had significant weight loss (67.3 vs. 63.2 kg, p < 0.01) and body mass index reduction (25.2 vs. 23.4, p < 0.01), there was significant increment of spine BMD (1.134 vs. 1.165 g/cm, p < 0.01) after 12-month follow-up. The TBS did not change over time.
Although lactation is associated with transient bone loss and body weight changes, the unchanged TBS could highlight a limited effectiveness in detecting dynamic bone properties in the first year postpartum.
尽管哺乳期与骨量一过性丢失和体重变化有关，但 TBS 不变可能突出表明在产后第一年检测动态骨骼特性的效果有限。
评估产后女性的小梁骨评分（TBS）和骨密度（BMD）。
这是一项为期 12 个月的前瞻性队列研究，纳入 40 名哺乳期产后女性和 44 名未怀孕女性。纳入标准如下：年龄在 18 至 35 岁之间，单胎足月（≥37 周）妊娠，12 个月内无妊娠计划。DXA 在产后 4 个不同时间点（1.产后 1 个月，2.产后 3-4 个月，3.产后 6-9 个月，4.产后≥12 个月）对脊柱、髋部、前臂和全身进行 BMD 测量。
BMD 测量结果显示，第 2 次评估（哺乳期高峰期）时脊柱（1.134 比 1.088 g/cm，p<0.01）、股骨颈（0.988 比 0.946 g/cm，p<0.01）、全股骨（0.971 比 0.933 g/cm，p<0.01）和全身（1.132 比 1.119 g/cm，p=0.03）均有统计学显著降低。第 3 次评估后脊柱早期恢复，所有骨骼部位均完全恢复。尽管哺乳期女性体重明显减轻（67.3 比 63.2 kg，p<0.01）和体重指数降低（25.2 比 23.4，p<0.01），但产后 12 个月随访时脊柱 BMD 显著增加（1.134 比 1.165 g/cm，p<0.01）。TBS 随时间无变化。
尽管哺乳期与骨量一过性丢失和体重变化有关，但 TBS 不变可能突出表明在产后第一年检测动态骨骼特性的效果有限。
