Taronga Conservation Society Australia, Taronga Western Plains Zoo, Dubbo, New South Wales, 2830 Australia,
Taronga Conservation Society Australia, Taronga Western Plains Zoo, Dubbo, New South Wales, 2830 Australia.
J Zoo Wildl Med. 2021 Jan;51(4):1025-1034. doi: 10.1638/2020-0006.
Mast cell tumors in nondomestic felids are rarely reported and their biological characteristics are not well described. A retrospective review of the pathology records of 52 zoo-housed cheetahs () identified five cases of mast cell tumor, involving four closely related individuals. The age at initial presentation varied from 14 mo to 6 yr. Four cases presented as solitary or multiple cutaneous masses that were mostly slow growing, up to 20 mm diameter, and predominantly nonulcerated. The diagnosis was made by fine needle aspiration cytology of a lesion in one case and by excisional biopsy in the others. Histopathologically, the lesions resembled low- to intermediate-grade canine mast cell tumors, with variations in the degree of anisocytosis and anisokaryosis. Surgical excision was incomplete for 80% of the cutaneous lesions, but local recurrence was not observed in any case. One animal with cutaneous lesions subsequently developed fatal visceral mastocytosis involving the spleen, liver, and adrenal gland. There was no evidence of lymph node invasion or paraneoplastic gastrointestinal signs in any of the cases.
非家养猫科动物的肥大细胞瘤很少见，其生物学特征尚未得到很好的描述。对 52 只圈养猎豹的病理学记录进行回顾性分析，确定了 5 例肥大细胞瘤病例，涉及 4 只密切相关的个体。首次就诊时的年龄从 14 月龄到 6 岁不等。4 例表现为孤立或多发性皮肤肿块，生长缓慢，最大直径达 20 毫米，主要无溃疡。1 例通过病变细针抽吸细胞学检查诊断，其余 3 例通过切除活检诊断。组织病理学上，病变类似于低至中级犬肥大细胞瘤，存在异形性和核多形性程度的差异。80%的皮肤病变手术切除不完全，但在任何情况下均未观察到局部复发。1 只患有皮肤病变的动物随后发生致命的内脏肥大细胞瘤，累及脾脏、肝脏和肾上腺。在任何病例中均未发现淋巴结侵犯或副肿瘤性胃肠道迹象。
