Psychological Center, West China Hospital, Sichuan University, Sichuan.
Shanghai Key Laboratory of Psychotic Disorders, Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai.
Clin Neuropharmacol. 2021;44(2):53-56. doi: 10.1097/WNF.0000000000000436.
Major depressive disorder (MDD) is a heterogeneous psychiatric disorder and considered to be one of the most common mental diseases worldwide. The antidepressant venlafaxine, as a serotonin noradrenaline reuptake inhibitor, is applied to MDD relief. Solute carrier family 6 member 4 (SLC6A4) has been reported to promote the reuptake of serotonin and to be closely correlated to depression. The present study examined whether rs6354 and rs1487971 in SLC6A4 are associated with remission after venlafaxine treatment in MDD patients.
This study consisted of 195 Han Chinese patients with MDD, who accepted a 6-week treatment with venlafaxine. Two SLC6A4 single-nucleotide polymorphisms (SNPs) were selected from database of SNP and genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometer in MassARRAY Analyzer 4 platforms. The 17-item Hamilton Depression Scale was used to access the severity of major depression. Allele and genotype frequencies between patients in remission and nonremission were calculated with online software SHEsis.
No significant differences in allele or genotype frequencies were observed in rs6354 and rs1487971. There were no significant associations between 2 SNPs and venlafaxine treatment outcome.
It suggested that rs6354 or rs1487971 within SLC6A4 appears not to be involved in the venlafaxine treatment outcome in Han Chinese patients with MDD.
重度抑郁症（MDD）是一种异质性精神障碍，被认为是全世界最常见的精神疾病之一。抗抑郁药文拉法辛作为一种 5-羟色胺和去甲肾上腺素再摄取抑制剂，用于缓解 MDD。溶质载体家族 6 成员 4（SLC6A4）已被报道可促进 5-羟色胺的再摄取，与抑郁密切相关。本研究探讨了 SLC6A4 中的 rs6354 和 rs1487971 是否与 MDD 患者接受文拉法辛治疗后的缓解相关。
本研究包括 195 名接受文拉法辛治疗 6 周的汉族 MDD 患者。从 SNP 数据库中选择了两个 SLC6A4 单核苷酸多态性（SNP），并在 MassARRAY Analyzer 4 平台的基质辅助激光解吸/电离飞行时间质谱仪中进行基因分型。使用 17 项汉密尔顿抑郁量表评估重度抑郁的严重程度。通过在线软件 SHEsis 计算缓解和未缓解患者之间的等位基因和基因型频率。
未观察到 rs6354 和 rs1487971 的等位基因或基因型频率存在显著差异。2 个 SNP 与文拉法辛治疗结果之间没有显著关联。
这表明 SLC6A4 中的 rs6354 或 rs1487971 似乎不参与汉族 MDD 患者的文拉法辛治疗结局。
