Department of Ophthalmology, University of California, San Francisco, San Francisco, California; and.
Department of Ophthalmology, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Retina. 2021 May 1;41(5):1137-1139. doi: 10.1097/IAE.0000000000003123.
To report the clinicopathologic correlation and biochemical analysis of silicone oil removed after 23 years in an eye.
A 63-years-old man with a history of HIV/AIDS and cytomegalovirus retinitis, status post retinal detachment repair with silicone oil at the age of 39 years, presented with several weeks of worse vision. He was found to have a shallow fovea-off tractional retinal detachment. After the silicone oil was removed during retinal detachment repair, it was analyzed by Fourier-transform infrared spectroscopy and gas chromatography with mass spectrometry.
In addition to cyclic and linear silicone oil, cholesterol was found in the removed silicone oil, which was not present in unused silicone oil samples. No other chemical alterations were identified in the extracted silicone oil.
Silicone oil left inside an eye over an extended period may extract lipophilic substances from adjacent tissue, with possible pathophysiologic effects. However, no other major potentially toxic substance was identified from the long-standing silicone oil sample, suggesting relative chemical stability of the tamponade agent over time.
报告一例硅油取出术后 23 年的临床病理相关性和生物化学分析。
一名 63 岁男性，既往有 HIV/AIDS 和巨细胞病毒视网膜炎病史，39 岁时因孔源性视网膜脱离行硅油填充视网膜复位术，术后 23 年因视力下降数周就诊。检查发现患者存在浅凹脱离的牵拉性视网膜脱离。在进行视网膜脱离修复时将硅油取出，通过傅里叶变换红外光谱和气相色谱-质谱联用技术对其进行分析。
除了环状和线性硅油外，还在取出的硅油中发现了胆固醇，而在未使用的硅油样本中则没有发现胆固醇。在提取的硅油中没有发现其他化学变化。
在眼内长时间留置的硅油可能会从周围组织中提取亲脂性物质，从而产生潜在的病理生理影响。然而，从长期的硅油样本中没有发现其他潜在的有毒物质，这表明这种眼内填充物在一段时间内具有相对稳定的化学性质。
