Bagshaw R J, Cox R H
Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia.
Acta Anaesthesiol Scand. 1988 Feb;32(2):82-92. doi: 10.1111/j.1399-6576.1988.tb02693.x.
Central and regional hemodynamics were studied at five levels of carotid sinus baroreceptor stimulation and three isoflurane levels. Apart from iliac blood flow, all regional blood flows, together with mean aortic pressure, power and flow decreased in response to an increasing anesthetic level and/or carotid sinus baroreceptor stimulation. These effects were additive with no significant interaction between the two experimental factors. At the carotid sinus reflex set point pressure, isoflurane attenuated the ability of carotid sinus baroreceptors to change mean aortic pressure and power together with the maximum capacity of the carotid sinus baroreceptors to produce vasoconstriction. The maximum capacity of the carotid sinus baroreceptors to produce vasodilation was unaffected by isoflurane. Vagotomy only modified hemodynamic set point values at low isoflurane levels, increasing regional resistances at the expense of flow except for the iliac bed. Following vagotomy, reflex gain was increased as was the maximum capacity of the cardiovascular system to vasoconstrict and vasodilate in response to carotid sinus pressure stimulation, together with the range of arterial pressure control.
在五个水平的颈动脉窦压力感受器刺激和三个异氟烷水平下研究了中心和区域血流动力学。除了髂血流外，所有区域血流以及平均主动脉压、功率和流量均随着麻醉水平的升高和/或颈动脉窦压力感受器刺激而降低。这些效应是相加的，两个实验因素之间无显著交互作用。在颈动脉窦反射设定点压力下，异氟烷减弱了颈动脉窦压力感受器改变平均主动脉压和功率的能力，以及颈动脉窦压力感受器产生血管收缩的最大能力。颈动脉窦压力感受器产生血管舒张的最大能力不受异氟烷影响。迷走神经切断术仅在低异氟烷水平下改变血流动力学设定点值，除髂床外，以牺牲血流为代价增加区域阻力。迷走神经切断术后，反射增益增加，心血管系统对颈动脉窦压力刺激产生血管收缩和舒张的最大能力以及动脉压控制范围也增加。
