Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Health Services & Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Age Ageing. 2021 Jun 28;50(4):1236-1242. doi: 10.1093/ageing/afaa276.
The relationship between self-reported visual disability and cognitive impairment in older individuals is unclear.
To determine the relationship of vision-specific functioning (VSF), vision-specific mobility (VSM) and visual acuity (VA) with clinically assessed cognitive impairment in the Epidemiology of Dementia in Singapore study.
Cross-sectional.
Population-based.
Eight hundred and seventy-four adults aged ≥60 years at higher risk of possible cognitive impairment by the Abbreviated Mental Test and progressive forgetfulness question.
VSF and VSM were measured using Rasch-transformed continuous scores of two Impact of Vision Impairment questionnaire domains. Cognitive impairment was objectively determined using detailed neuropsychological testing and defined as no cognitive impairment (NCI), mild cognitive impairment-no dementia (CIND), moderate CIND only and moderate CIND or dementia. Associations were assessed using multinomial logistic regression models.
Of the 874 participants (49.0% males, mean age (SD) 65.5 (7.0) years), 277, 281 and 316 had NCI, mild CIND and moderate CIND or dementia, respectively. Compared to NCI, the odds of moderate CIND, and moderate CIND or dementia increased for every SD worsening in VSF (OR: 1.44, 95% CI 1.14-1.82, and OR: 1.52, 95%CI 1.19-1.94, respectively) and VSM (OR: 1.42, 95%CI 1.11-1.81, and OR: 1.50, 95%CI 1.15-1.95). Similarly, the odds of mild CIND (OR: 1.62, 95%CI 1.19-2.22), moderate CIND (OR: 1.93, 95%CI 1.45-2.58), and moderate CIND or dementia (OR: 2.25, 95%CI 1.62-3.11) increased significantly with every SD worsening of VA.
Our results emphasise the importance of interventions to prevent vision loss and improve quality of life to reduce likelihood of age-related cognitive decline.
老年人中自我报告的视力障碍与认知障碍之间的关系尚不清楚。
在新加坡痴呆症流行病学研究中，确定特定于视力的功能（VSF）、特定于视力的移动性（VSM）和视力（VA）与临床评估的认知障碍之间的关系。
横断面。
基于人群。
874 名年龄在 60 岁及以上、有较高可能存在认知障碍风险的成年人，通过简易精神状态检查和持续性遗忘问题进行评估。
使用两个影响视力障碍问卷领域的 Rasch 转化连续分数来测量 VSF 和 VSM。使用详细的神经心理学测试客观地确定认知障碍，并定义为无认知障碍（NCI）、轻度认知障碍无痴呆（CIND）、中度 CIND 仅和中度 CIND 或痴呆。使用多项逻辑回归模型评估关联。
在 874 名参与者中（49.0%为男性，平均年龄（标准差）65.5（7.0）岁），277、281 和 316 名参与者分别患有 NCI、轻度 CIND 和中度 CIND 或痴呆。与 NCI 相比，VSF（OR：1.44，95%CI 1.14-1.82，和 OR：1.52，95%CI 1.19-1.94）和 VSM（OR：1.42，95%CI 1.11-1.81，和 OR：1.50，95%CI 1.15-1.95）每标准差恶化时，中度 CIND 和中度 CIND 或痴呆的可能性增加。同样，轻度 CIND（OR：1.62，95%CI 1.19-2.22）、中度 CIND（OR：1.93，95%CI 1.45-2.58）和中度 CIND 或痴呆（OR：2.25，95%CI 1.62-3.11）的可能性随着 VA 的每标准差恶化而显著增加。
我们的研究结果强调了干预措施预防视力丧失和提高生活质量以降低与年龄相关的认知能力下降的重要性。
