Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Üniversiteler Mh., Bilkent Blv, 06800, Ankara, Turkey.
Faculty of Medicine, Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital, Ankara, Turkey.
Int Ophthalmol. 2021 Apr;41(4):1373-1379. doi: 10.1007/s10792-021-01701-8. Epub 2021 Jan 22.
Prolactinoma is a type of pituitary tumour that produces an excessive amount of the hormone prolactin. It is the most common type of hormonally-active pituitary tumour. These tumours can cause ocular complications such as vision loss and visual fields (VF) defect. In this study, we aimed to evaluate the thickness of chorioretinal layers in patients with prolactinoma.
We enrolled 63 eyes of 32 prolactinoma patients and 36 eyes of 18 age and gender-matched healthy controls. All participants underwent complete hormonal and ophthalmological examination, including spectral-domain optical coherence tomography (SD-OCT) and VF test.The complete biochemical response was defined as serum PRL concentration ≤ 20 ng/mL at the time of evaluation.The seven layers were retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and retinal pigment epithelium (RPE). The results of prolactinoma patients were compared with the control group.
The mean RNFL, GCL, IPL, INL, ONL, and RPE were thinner in prolactinoma patients than the control group (p < 0.05) while OPL was similar between groups (p > 0.05).None of the patients had VF defect.The thickness of retinal layers was similar in patients with and without complete biochemical response (p > 0.05).
To our knowledge, this is the first study that evaluates the thickness of chorioretinal layers in patients with prolactinoma.Most of the layers were thinner than the control group.Therefore, detailed eye assessment should be a routine component of the follow-up visits of prolactinoma patients and further studies related to this condition are required.
催乳素瘤是一种产生过量催乳素的垂体肿瘤。它是最常见的功能性垂体肿瘤。这些肿瘤可导致眼部并发症，如视力丧失和视野（VF）缺陷。在这项研究中，我们旨在评估催乳素瘤患者的脉络膜视网膜层厚度。
我们纳入了 32 名催乳素瘤患者的 63 只眼和 18 名年龄和性别匹配的健康对照者的 36 只眼。所有参与者均接受了完整的激素和眼科检查，包括谱域光相干断层扫描（SD-OCT）和 VF 测试。完全生化缓解定义为评估时血清 PRL 浓度≤20ng/mL。该研究将视网膜神经纤维层（RNFL）、节细胞层（GCL）、内丛状层（IPL）、内核层（INL）、外丛状层（OPL）、外核层（ONL）和视网膜色素上皮（RPE）分为 7 层。将催乳素瘤患者的结果与对照组进行比较。
催乳素瘤患者的平均 RNFL、GCL、IPL、INL、ONL 和 RPE 均比对照组薄（p<0.05），而 OPL 在两组间相似（p>0.05）。无患者存在 VF 缺陷。生化缓解完全和不完全的患者视网膜层厚度相似（p>0.05）。
据我们所知，这是第一项评估催乳素瘤患者脉络膜视网膜层厚度的研究。大多数层都比对照组薄。因此，详细的眼部评估应成为催乳素瘤患者随访的常规组成部分，并且需要进一步研究与该疾病相关的研究。
