Marshall Z T, Lippmann S B
University of Cincinnati School of Medicine, Ohio.
Am Fam Physician. 1988 Mar;37(3):251-4.
Plasma concentrations of tricyclic antidepressant drugs vary widely among patients. At routine dosage, unexpectedly low plasma levels are noted in some patients, while toxic levels can occur in others. Individual variability may be due to genetic differences in metabolism or to other factors including drug interactions and poor compliance. Pharmacologic management of depressed patients is often improved when guided by plasma concentration monitoring.
三环类抗抑郁药物的血浆浓度在患者之间差异很大。在常规剂量下，一些患者会出现意外的低血浆水平，而另一些患者则可能出现中毒水平。个体差异可能是由于代谢的基因差异或其他因素，包括药物相互作用和依从性差。在血浆浓度监测的指导下，抑郁症患者的药物治疗通常会得到改善。
