Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Am J Dermatopathol. 2021 May 1;43(5):373-376. doi: 10.1097/DAD.0000000000001903.
Chronic arsenism usually occurs after a long-term unawareness of arsenic exposure from environment, occupation, food, and water. We here reported 3 cases with diffused arsenic keratosis and skin cancers derived from long-term arsenic medication ingestion. In these cases, hyperkeratotic skin lesions were initially found on palms and soles, slowly progressed to every part of the skin and lasted maximally for over 30 years. Skin cancers were diagnosed and removed intermittently within decades, but with no malignancies in other organs. Oral retinoids combing with topical 5- fluorouracil and photodynamic treatment yielded a desirable outcome.
慢性砷中毒通常是由于长期暴露于环境、职业、食物和水中的砷而未被察觉引起的。我们在此报告了 3 例因长期服用砷剂而导致弥漫性砷角化病和皮肤癌的病例。在这些病例中，角化过度性皮损最初出现在手掌和脚底，然后缓慢进展到皮肤的各个部位，最长可持续 30 多年。皮肤癌在几十年间间断被诊断和切除，但其他器官没有恶性肿瘤。口服维甲酸联合外用 5-氟尿嘧啶和光动力治疗取得了良好的效果。
