红细胞中仅忠实针对单个靶基因的锌指转录因子。
A Zinc Finger Transcription Factor Faithfully Dedicated to Only a Single Target Gene in Erythroid Cells.
机构信息
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Mol Cell. 2021 Jan 21;81(2):218-219. doi: 10.1016/j.molcel.2020.12.023.
PMID:33482089
Abstract
Lan et al. carry out a CRISPR-mediated genetic screen and discover that ZNF410 uniquely regulates the NuRD component CHD4 to repress γ-globin transcription in erythroid cells, establishing a novel fetal hemoglobin regulatory mechanism.
摘要
兰等人开展了一项 CRISPR 介导的遗传筛选，发现 ZNF410 特异性调节 NuRD 成分 CHD4 以抑制红细胞中的 γ-珠蛋白转录，建立了一种新的胎儿血红蛋白调控机制。
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