Fetal hemoglobin induction in sickle erythroid progenitors using a synthetic zinc finger DNA-binding domain.
作者信息
Li Biaoru, Zhu Xingguo, Hossain Mir A, Guy Cameron R, Xu Hongyan, Bungert Jörg, Pace Betty S
机构信息
Department of Pediatrics, Augusta University, GA.
Department of Biochemistry and Molecular Biology, College of Medicine, Health Cancer Center, Center for Epigenetics, Genetics Institute, University of Florida, Gainesville, FL.
出版信息
Haematologica. 2018 Sep;103(9):e384-e387. doi: 10.3324/haematol.2017.185967. Epub 2018 Apr 5.
Abstract
摘要
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本文引用的文献
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Fetal haemoglobin induction in sickle cell disease.镰状细胞病中胎儿血红蛋白的诱导
Br J Haematol. 2018 Jan;180(2):189-200. doi: 10.1111/bjh.15021. Epub 2017 Nov 16.
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Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.富马酸二甲酯可增加胎儿血红蛋白，提供血红素解毒，并纠正镰状细胞病的贫血。
JCI Insight. 2017 Oct 19;2(20):96409. doi: 10.1172/jci.insight.96409.
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Curative approaches for sickle cell disease: A review of allogeneic and autologous strategies.镰状细胞病的治疗方法：异体和自体策略综述。
Blood Cells Mol Dis. 2017 Sep;67:155-168. doi: 10.1016/j.bcmd.2017.08.014. Epub 2017 Sep 1.
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Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.口服四氢尿苷和地西他滨用于镰状细胞病的非细胞毒性表观遗传基因调控：一项随机1期研究。
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NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors.NRF2介导人类红系祖细胞中的γ-珠蛋白基因调控和胎儿血红蛋白诱导。
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Gene Therapy in a Patient with Sickle Cell Disease.基因治疗镰状细胞病患者。
N Engl J Med. 2017 Mar 2;376(9):848-855. doi: 10.1056/NEJMoa1609677.
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Intravascular hemolysis and the pathophysiology of sickle cell disease.血管内溶血与镰状细胞病的病理生理学
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Regulation of disease-associated gene expression in the 3D genome.三维基因组中疾病相关基因表达的调控。
Nat Rev Mol Cell Biol. 2016 Dec;17(12):771-782. doi: 10.1038/nrm.2016.138. Epub 2016 Nov 9.
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Activation of Fetal γ-globin Gene Expression via Direct Protein Delivery of Synthetic Zinc-finger DNA-Binding Domains.通过合成锌指DNA结合结构域的直接蛋白质递送激活胎儿γ-珠蛋白基因表达
Mol Ther Nucleic Acids. 2016 Oct 18;5(10):e378. doi: 10.1038/mtna.2016.85.
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