钙调磷酸酶：一颗新星的诞生。
Calcineurin: A star is reborn.
机构信息
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.
La Jolla Institute for Immunology, La Jolla, CA, 92037, USA; Moores Cancer Center, University of California-San Diego, La Jolla, CA, 92093, USA.
出版信息
Cell Calcium. 2021 Mar;94:102324. doi: 10.1016/j.ceca.2020.102324. Epub 2021 Jan 12.
Abstract
The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.
摘要
钙调神经磷酸酶（calcineurin）这种蛋白磷酸酶长期以来一直为钙学界所熟悉，但它的生理底物的定义却远未完全清楚。一项新的研究纠正了这一不足，为深入了解钙调神经磷酸酶在各种细胞过程中的作用奠定了基础。
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Mol Cell. 2020 Jul 16;79(2):342-358.e12. doi: 10.1016/j.molcel.2020.06.029. Epub 2020 Jul 8.
2
Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates.利用 LxVP SLiM 的新定义发现新型钙调神经磷酸酶调节剂和底物。
ACS Chem Biol. 2019 Dec 20;14(12):2672-2682. doi: 10.1021/acschembio.9b00606. Epub 2019 Nov 1.
3
Identifying New Substrates and Functions for an Old Enzyme: Calcineurin.鉴定一种古老酶的新底物和新功能：钙调磷酸酶。
Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3):a035436. doi: 10.1101/cshperspect.a035436.
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Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.利用 πɸLxVP SLiM 研究人类钙调神经磷酸酶相互作用网络。
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The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.钙调神经磷酸酶的底物结合和免疫抑制剂抑制的分子机制。
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