Research and Development Department, Pure Biologics, Inc., Dunska 11, 54427, Wrocław, Poland.
J Biomed Sci. 2021 Jan 22;28(1):11. doi: 10.1186/s12929-021-00709-7.
Therapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly explored in this field are pH-responsive antibodies capable of binding target antigens in a pH-dependent manner. We reviewed suitability and examples of these antibodies that are functionally modulated by the tumor microenvironment. Provided in this review is an update about antigens targeted by pH-responsive, sweeping, and recycling antibodies. Applicability of the pH-responsive antibodies in the engineering of chimeric antigen receptor T-cells (CAR-T) and in improving drug delivery to the brain by the enhanced crossing of the blood-brain barrier is also discussed. The pH-responsive antibodies possess strong treatment potential. They emerge as next-generation programmable engineered biologic drugs that are active only within the targeted biological space. Thus, they are valuable in targeting acidified tumor microenvironment because of improved spatial persistence and reduced on-target off-tumor toxicities. We predict that the programmable pH-dependent antibodies become powerful tools in therapies of cancer.
治疗性抗体在改善某些疾病状况的治疗效果方面发挥了重要作用。然而，为了提高它们的疗效和特异性，许多努力正在不断进行。在这个领域中越来越受到关注的方法之一是 pH 响应性抗体，它能够以 pH 依赖的方式结合靶抗原。我们综述了这些抗体的适用性和实例，这些抗体的功能受肿瘤微环境调节。本综述提供了关于 pH 响应性、广谱和循环抗体靶向抗原的最新信息。还讨论了 pH 响应性抗体在嵌合抗原受体 T 细胞（CAR-T）工程中的应用，以及通过增强血脑屏障通透性改善药物向大脑的递送。pH 响应性抗体具有很强的治疗潜力。它们作为新一代可编程工程生物药物出现，仅在靶向生物空间内具有活性。因此，由于空间持久性提高和靶外肿瘤毒性降低，它们在靶向酸化肿瘤微环境方面具有重要价值。我们预测，可编程 pH 依赖性抗体将成为癌症治疗的有力工具。
Zotero 插件
