Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.
Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.
J Diabetes Complications. 2021 Apr;35(4):107850. doi: 10.1016/j.jdiacomp.2021.107850. Epub 2021 Jan 9.
To examine the effects of strict glycemic control on the birthweight of infants born to Japanese patients with early- or mid-to-late-detected gestational diabetes mellitus (ed- or md-GDM).
We retrospectively examined the characteristics of 101 patients with GDM who underwent guideline-based glycemic control. A 75-g oral glucose tolerance test was conducted to diagnose GDM at gestational weeks 11-15 (ed-GDM subgroup) and 24-28 (md-GDM subgroup).
Infant birthweight was significantly lower in the ed-GDM subgroup (n = 25) than in the md-GDM subgroup (n = 76) (2688.3 ± 470.4 g vs. 3052.4 ± 383.1 g, p < 0.05), and the proportion of low-birthweight infants (<2500 g) was significantly higher in the ed-GDM subgroup than in the md-GDM subgroup (32.0% vs. 5.3%, p < 0.005). Fasting plasma glucose (FPG) levels during early treatment and before delivery were significantly lower in the ed-GDM subgroup than in the md-GDM subgroup (76.1 ± 10.4 mg/dL vs. 85.5 ± 9.6 mg/dL, p < 0.001; 80.5 ± 10.4 mg/dL vs. 90.4 ± 10.3 mg/dL, p < 0.0001).
Patients with ed-GDM showed significantly lower FPG levels during treatment compared to those with md-GDM, presumably indicating an association with the delivery of low-birthweight infants.
探讨严格血糖控制对日本早发或中晚发妊娠期糖尿病（ed-GDM 或 md-GDM）患者所娩婴儿出生体重的影响。
我们回顾性分析了 101 例接受基于指南的血糖控制的 GDM 患者的特征。在妊娠 11-15 周（ed-GDM 亚组）和 24-28 周（md-GDM 亚组）进行 75g 口服葡萄糖耐量试验以诊断 GDM。
ed-GDM 亚组（n=25）的婴儿出生体重明显低于 md-GDM 亚组（n=76）（2688.3±470.4g 比 3052.4±383.1g，p<0.05），ed-GDM 亚组低出生体重儿（<2500g）的比例也明显高于 md-GDM 亚组（32.0%比 5.3%，p<0.005）。ed-GDM 亚组治疗早期和分娩前的空腹血糖（FPG）水平明显低于 md-GDM 亚组（76.1±10.4mg/dL 比 85.5±9.6mg/dL，p<0.001；80.5±10.4mg/dL 比 90.4±10.3mg/dL，p<0.0001）。
与 md-GDM 患者相比，ed-GDM 患者治疗期间的 FPG 水平明显较低，这可能与低出生体重儿的分娩有关。
