Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Obstetrics and Gynecology, Wenzhou People Hospital, Wenzhou, China.
Int J Gynaecol Obstet. 2022 Jan;156(1):77-81. doi: 10.1002/ijgo.13615. Epub 2021 Feb 17.
To study the effect of delayed cord clamping (DCC) on the bilirubin levels and hypoglycemia in neonates with diabetic mothers (NDMs).
This is a comparison between a prospective cohort and a historical control cohort. Women with gestational diabetes mellitus who performed DCC were enrolled into the prospective cohort (n = 156), and those who performed early cord clamping (ECC) were enrolled into the historical control cohort (n = 161).
NDMs who received DCC had higher transcutaneous bilirubin than those in the ECC group whether maternal glycemic control was good or poor. DCC increased the rate of neonatal hyperbilirubinemia and phototherapy when maternal blood glucose was well controlled but not when it was poorly controlled. No differences were found in initial blood glucose levels on days 1 to 3 of life between the two groups.
Delayed cord clamping increased bilirubin levels, the risk of neonatal hyperbilirubinemia, and phototherapy in IDMs without improved initial blood glucose levels. Therefore, DCC was not recommended in NDMs.
研究延迟脐带夹闭（DCC）对糖尿病母亲新生儿（NDMs）胆红素水平和低血糖的影响。
这是一项前瞻性队列研究和历史对照队列研究的比较。对行 DCC 的妊娠期糖尿病女性纳入前瞻性队列（n=156），行早期脐带夹闭（ECC）的女性纳入历史对照队列（n=161）。
无论母体血糖控制情况如何，行 DCC 的 NDMs 的经皮胆红素均高于 ECC 组。当母体血糖控制良好时，DCC 会增加新生儿高胆红素血症和光疗的发生率，但当血糖控制不佳时则不会。两组在生命的第 1 至 3 天之间的初始血糖水平无差异。
延迟脐带夹闭会增加 IDMs 的胆红素水平、新生儿高胆红素血症和光疗的风险，而不会改善初始血糖水平。因此，不建议在 NDMs 中使用 DCC。
