Xa 因子：凝血酶原激酶，从保罗·莫拉维茨到哈斯克尔·米尔斯坦。
Factor Xa: Thrombokinase from Paul Morawitz to J Haskell Milstone.
机构信息
Department of Dermatology, Yale Medical School, 333 Cedar St, New Haven, CT, 06520-8059, USA.
出版信息
J Thromb Thrombolysis. 2021 Aug;52(2):364-370. doi: 10.1007/s11239-021-02387-6. Epub 2021 Jan 23.
PMID:33484373
Abstract
In 1904 Paul Morawitz postulated that an enzyme, which he named thrombokinase, would be the primary activator of prothrombin. Fifty years passed before J Haskell Milstone isolated, purified and functionally characterized the enzyme we now call Factor Xa. This essay summarizes Milstone's work on thrombokinase, and finds context for why his efforts succeeded while others struggled.
摘要
1904 年，Paul Morawitz 推测一种名为凝血激酶的酶将是凝血酶原的主要激活剂。五十年过去了，J Haskell Milstone 才分离、纯化并从功能上鉴定了我们现在称之为因子 Xa 的酶。本文总结了 Milstone 在凝血激酶方面的工作，并探讨了他的努力为何成功而其他人却苦苦挣扎的原因。
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