Sams R A, Muir W W
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Am J Vet Res. 1988 Feb;49(2):245-9.
The effects of phenobarbital on the pharmacokinetics of thiopental (15 mg/kg IV) were investigated in 12 trained racing Greyhounds. Phenobarbital (16 mg/kg of body weight, PO, q 24 h), administered for 14 days, reduced the area under the curve of plasma concentration of thiopental vs time from 10,688 micrograms.min/ml to 3,224 micrograms.min/ml. Furthermore, the time to recovery from anesthesia (ie, return to standing position) decreased from 103 minutes to 35.7 minutes after phenobarbital. These effects were attributed to an increase in the metabolic clearance of thiopental, as a result of induction of liver enzyme activity by phenobarbital. These results suggested that hepatic metabolism, in addition to distribution, is a factor that must be considered when assessing the difference in drug disappearance rates between Greyhounds and other breeds of dogs.
在12只训练有素的赛犬中研究了苯巴比妥对硫喷妥钠（静脉注射15mg/kg）药代动力学的影响。连续14天给予苯巴比妥（16mg/kg体重，口服，每24小时一次）后，硫喷妥钠血浆浓度-时间曲线下面积从10688μg·min/ml降至3224μg·min/ml。此外，苯巴比妥给药后，从麻醉中恢复（即恢复站立姿势）的时间从103分钟缩短至35.7分钟。这些作用归因于苯巴比妥诱导肝酶活性，从而增加了硫喷妥钠的代谢清除率。这些结果表明，在评估灵缇犬与其他品种犬之间药物消失率差异时，除分布外，肝脏代谢也是一个必须考虑的因素。
