新型二氟喹诺酮NY-198在大鼠体内的肠肝循环
Enterohepatic circulation of NY-198, a new difluorinated quinolone, in rats.
作者信息
Saito A, Nagata O, Takahara Y, Okezaki E, Yamada T, Ito Y
机构信息
College of Medical Technology, Hokkaido University, Sapporo, Japan.
出版信息
Antimicrob Agents Chemother. 1988 Jan;32(1):156-7. doi: 10.1128/AAC.32.1.156.
Abstract
Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.
摘要
对大鼠体内NY - 198的肠肝循环进行了研究。胆汁中的NY - 198葡糖醛酸苷被肠内容物迅速水解为NY - 198。胆汁中水解后的NY - 198和母体NY - 198从肠道重新吸收。肠肝循环中的NY - 198量为胆汁中排泄量的59.8%。
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