• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

在常规临床实践中减轻体重和体重反弹:来自 TARGET-NASH 观察性队列的结果。

Weight Loss and Weight Regain in Usual Clinical Practice: Results From the TARGET-NASH Observational Cohort.

机构信息

Tampa General Hospital, Tampa, Florida.

Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

出版信息

Clin Gastroenterol Hepatol. 2022 Oct;20(10):2393-2395.e4. doi: 10.1016/j.cgh.2021.01.023. Epub 2021 Jan 21.

DOI:10.1016/j.cgh.2021.01.023
PMID:33486083
Abstract

First-line treatment for nonalcoholic fatty liver disease (NAFLD) focuses on weight loss through lifestyle modifications. Weight loss ≥5% results in reduction of steatosis and weight loss ≥10% has been associated with improvement in hepatic inflammation and fibrosis. The incidence and sustainability of weight loss among patients with NAFLD were estimated and associating factors identified.

摘要

非酒精性脂肪性肝病 (NAFLD) 的一线治疗方法侧重于通过生活方式改变来减轻体重。体重减轻≥5%可导致脂肪变性减少,体重减轻≥10%与肝炎症和纤维化改善相关。估计了 NAFLD 患者的减重发生率和可持续性,并确定了相关因素。

相似文献

1
Weight Loss and Weight Regain in Usual Clinical Practice: Results From the TARGET-NASH Observational Cohort.在常规临床实践中减轻体重和体重反弹:来自 TARGET-NASH 观察性队列的结果。
Clin Gastroenterol Hepatol. 2022 Oct;20(10):2393-2395.e4. doi: 10.1016/j.cgh.2021.01.023. Epub 2021 Jan 21.
2
Lifestyle intervention for morbid obesity: effects on liver steatosis, inflammation, and fibrosis.生活方式干预治疗病态肥胖:对肝脏脂肪变性、炎症和纤维化的影响。
Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1;315(3):G329-G338. doi: 10.1152/ajpgi.00044.2018. Epub 2018 Jun 7.
3
Design and rationale for a real-world observational cohort of patients with nonalcoholic fatty liver disease: The TARGET-NASH study.非酒精性脂肪性肝病患者真实世界观察性队列的设计与原理:TARGET-NASH研究
Contemp Clin Trials. 2017 Oct;61:33-38. doi: 10.1016/j.cct.2017.07.015. Epub 2017 Jul 19.
4
Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.通过生活方式改变减轻体重可显著改善非酒精性脂肪性肝炎的特征。
Gastroenterology. 2015 Aug;149(2):367-78.e5; quiz e14-5. doi: 10.1053/j.gastro.2015.04.005. Epub 2015 Apr 10.
5
Effect of Weight Loss, Diet, Exercise, and Bariatric Surgery on Nonalcoholic Fatty Liver Disease.减肥、饮食、运动和减重手术对非酒精性脂肪性肝病的影响。
Clin Liver Dis. 2016 May;20(2):339-50. doi: 10.1016/j.cld.2015.10.008. Epub 2016 Feb 17.
6
Non-alcoholic fatty liver disease and lifestyle modifications, focusing on physical activity.非酒精性脂肪性肝病与生活方式改变,重点关注体育活动。
Korean J Intern Med. 2018 Jan;33(1):64-74. doi: 10.3904/kjim.2017.343. Epub 2017 Dec 6.
7
Lifestyle and Dietary Interventions in the Management of Nonalcoholic Fatty Liver Disease.非酒精性脂肪性肝病管理中的生活方式与饮食干预
Dig Dis Sci. 2016 May;61(5):1365-74. doi: 10.1007/s10620-016-4153-y.
8
Current Treatment of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis.非酒精性脂肪性肝病/非酒精性脂肪性肝炎的治疗现状。
Clin Liver Dis. 2018 Feb;22(1):175-187. doi: 10.1016/j.cld.2017.08.012. Epub 2017 Oct 21.
9
Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis.体重变化和生活方式改变对非酒精性脂肪性肝病发展或缓解的影响:基于性别差异的分析。
Sci Rep. 2020 Jan 16;10(1):481. doi: 10.1038/s41598-019-57369-9.
10
An internet-based approach for lifestyle changes in patients with NAFLD: Two-year effects on weight loss and surrogate markers.基于互联网的非酒精性脂肪性肝病患者生活方式改变方法:对体重减轻和替代标志物的两年影响。
J Hepatol. 2018 Nov;69(5):1155-1163. doi: 10.1016/j.jhep.2018.07.013. Epub 2018 Oct 2.

引用本文的文献

1
Pathological Evolution and Internal Medicine Management of Nonalcoholic Fatty Liver Disease (NAFLD) in the Era of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).代谢功能障碍相关脂肪性肝病(MASLD)时代非酒精性脂肪性肝病(NAFLD)的病理演变与内科管理
Cureus. 2025 Jun 29;17(6):e86963. doi: 10.7759/cureus.86963. eCollection 2025 Jun.
2
Pathogenesis and Clinical Management of Metabolic Dysfunction-Associated Steatotic Liver Disease.代谢功能障碍相关脂肪性肝病的发病机制与临床管理
Int J Mol Sci. 2025 Jun 14;26(12):5717. doi: 10.3390/ijms26125717.
3
Medications for Weight Loss and MASLD: A National Survey of Hepatology and Gastroenterology Provider Practices, Attitudes, and Knowledge Before Resmetirom.
减肥药物与代谢相关脂肪性肝病:在resmetirom之前对肝病学和胃肠病学医疗服务提供者的实践、态度及知识的全国性调查
J Clin Gastroenterol. 2025 Jun 23. doi: 10.1097/MCG.0000000000002147.
4
Dietary Intake of Major Minerals and Trace Elements in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Implications for Dietary Intervention.代谢功能障碍相关脂肪性肝病患者主要矿物质和微量元素的膳食摄入:对饮食干预的启示
Adv Ther. 2025 May 29. doi: 10.1007/s12325-025-03238-z.
5
ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease.美国胃肠病学会临床指南:肝病中的营养不良与营养建议
Am J Gastroenterol. 2025 May 1;120(5):950-972. doi: 10.14309/ajg.0000000000003379. Epub 2025 May 2.
6
Metabolic dysfunction-associated steatotic liver disease in adults.成人代谢功能障碍相关脂肪性肝病
Nat Rev Dis Primers. 2025 Mar 6;11(1):14. doi: 10.1038/s41572-025-00599-1.
7
Evidence summary of lifestyle interventions in adults with metabolic dysfunction-associated steatotic liver disease.成人代谢功能障碍相关脂肪性肝病生活方式干预的证据总结
Front Nutr. 2025 Jan 6;11:1421386. doi: 10.3389/fnut.2024.1421386. eCollection 2024.
8
Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024).《代谢功能障碍相关脂肪性肝病防治指南(2024年版)》
J Clin Transl Hepatol. 2024 Nov 28;12(11):955-974. doi: 10.14218/JCTH.2024.00311. Epub 2024 Nov 4.
9
Treatment Options and Continuity of Care in Metabolic-associated Fatty Liver Disease: A Multidisciplinary Approach.代谢相关脂肪性肝病的治疗选择与照护连续性:多学科方法
Eur Cardiol. 2024 Jun 19;19:e06. doi: 10.15420/ecr.2023.34. eCollection 2024.
10
The Impact of Metabolic Health and Obesity on Liver Transplant Candidates and Recipients.代谢健康与肥胖对肝移植候选者及受者的影响。
Life (Basel). 2024 May 27;14(6):685. doi: 10.3390/life14060685.