Shiio T, Ohishi K, Niitsu I, Hayashibara H, Tsuchiya Y, Yoshihama T, Moriyuki H
Life Science Laboratory, Ajinonoto Co. Inc.
Gan To Kagaku Ryoho. 1988 Mar;15(3):481-5.
Combination effect of lentinan with X-ray irradiation on the metastatic mouse tumors, L1210, KLN205 and Lewis lung carcinoma were studied. Combination use of lentinan with X-ray therapy prolonged the life of BDF1 mice bearing L1210 leukemia in the suitable combination conditions. Combination effects of lentinan with X-ray therapy were also observed on the suppression of the growth of KLN205 squamous cell carcinoma and on the suppression of the metastasis of Lewis lung carcinoma. Especially, in the case that lentinan was administered before or after X-ray local irradiation in the pulmonary metastasis system of Lewis lung carcinoma, a marked suppression of pulmonary metastasis was observed and 2 to 4 mice among 8 tested mice were tumor free.
研究了香菇多糖与X射线照射对转移性小鼠肿瘤L1210、KLN205和Lewis肺癌的联合作用。在合适的联合条件下，香菇多糖与X射线治疗联合使用可延长携带L1210白血病的BDF1小鼠的寿命。还观察到香菇多糖与X射线治疗对抑制KLN205鳞状细胞癌生长和抑制Lewis肺癌转移的联合作用。特别是，在Lewis肺癌肺转移系统中，在X射线局部照射之前或之后给予香菇多糖的情况下，观察到肺转移受到明显抑制，8只受试小鼠中有2至4只无肿瘤。
