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首发精神病患者社会康复治疗后社会功能的改善:治疗后社会认知和神经认知是否发生变化,它们是否预测治疗反应?

Improved social functioning following social recovery therapy in first episode psychosis: Do social cognition and neurocognition change following therapy, and do they predict treatment response?

机构信息

Institute for Mental Health, University of Birmingham, Birmingham, UK.

Institute for Mental Health, University of Birmingham, Birmingham, UK; Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Victoria, Australia.

出版信息

Schizophr Res. 2021 Feb;228:249-255. doi: 10.1016/j.schres.2020.12.023. Epub 2021 Jan 22.

Abstract

UNLABELLED

There is a need to develop and refine psychosocial interventions to improve functioning in First Episode Psychosis (FEP). Social cognition and neurocognition are closely linked to functioning in psychosis; examinations of cognition pre- and post- psychosocial intervention may provide insights into the mechanisms of these interventions, and identify which individuals are most likely to benefit.

METHOD

Cognition was assessed within a multi-site trial of Social Recovery Therapy (SRT) for individuals with FEP experiencing poor functioning (<30 h weekly structured activity). Fifty-nine participants were randomly allocated to the therapy group (SRT + Early intervention), and 64 were allocated to treatment as usual group (TAU - early intervention care). Social cognition and neurocognition were assessed at baseline and 9 months; assessors were blind to group allocation. It was hypothesized that social cognition would improve following therapy, and those with better social cognition prior to therapy would benefit the most from SRT.

RESULTS

There was no significant impact of SRT on individual neurocognitive or social cognitive variables, however, joint models addressing patterns of missingness demonstrate improvement across a number of cognitive outcomes following SRT. Further, regression analyses showed those who had better social cognition at baseline were most likely to benefit from the therapy (ß = 0.350; 95% CI = 0.830 to 8.891; p = .019).

CONCLUSION

It is not clear if SRT impacts on social cognitive or neurocognitive function, however, SRT may be beneficial in those with better social cognition at baseline.

摘要

未加标签

需要开发和完善心理社会干预措施,以改善首次发作精神病(FEP)患者的功能。社会认知和神经认知与精神病患者的功能密切相关;在心理社会干预之前和之后检查认知功能,可以深入了解这些干预措施的机制,并确定哪些个体最有可能受益。

方法

在一项针对社会康复治疗(SRT)的多中心试验中,对功能较差(每周结构化活动<30 小时)的 FEP 患者进行认知评估。59 名参与者被随机分配到治疗组(SRT+早期干预),64 名被分配到常规治疗组(TAU-早期干预护理)。在基线和 9 个月时评估社会认知和神经认知;评估者对分组分配情况不知情。假设治疗后社会认知会有所改善,并且治疗前社会认知较好的患者将从 SRT 中获益最多。

结果

SRT 对单个神经认知或社会认知变量没有显著影响,但是,解决缺失模式的联合模型表明,SRT 后许多认知结果都有所改善。此外,回归分析显示,那些在基线时社会认知能力较好的人最有可能从治疗中受益(ß=0.350;95%置信区间=0.830 至 8.891;p=0.019)。

结论

尚不清楚 SRT 是否会影响社会认知或神经认知功能,但是,对于基线时社会认知能力较好的患者,SRT 可能是有益的。

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