Al Zubaidi Alaa, Eid Mustafa Mahmood
College of Medicine, University of Diyala, Baqubah, Iraq.
Al Ain Hospital, Al Ain, United Arab Emirates.
Arch Gynecol Obstet. 2021 Sep;304(3):833-838. doi: 10.1007/s00404-021-05965-4. Epub 2021 Jan 24.
Ectopic pregnancy is a condition of enormous gynaecological priority. It occurs when fertilized ovum implants outside the uterine cavity. Ectopic pregnancy is estimated to be 1-2% of all-natural conception. This study aims to evaluate the role of the placental growth factor in the diagnosis of ectopic pregnancy.
A case-control study was conducted in (Baghdad) teaching hospital in (Baghdad, Iraq) over one year. The study includes 240 women: 120 women with first trimester (5-10) weeks viable intrauterine pregnancy, and 120 women with ectopic pregnancy.
There is a significant association observed in the placental growth factor mean (PLGF), which is lower in ectopic pregnancy than in intrauterine pregnancy. The range of PLGF was less than 50 pg/mL in ectopic pregnancy, while it was up to 800 pg/mL in intrauterine pregnancy. In an ectopic pregnancy with a cut-off PLGF level of ≤ 15.5 pg/mL, the PLGF had a sensitivity of (92.5%), a specificity of (82.5%), a positive predictive value of (91.8%), a negative predictive value of (83.5%), and an accuracy of (90%). Different factors can affect PLGF, like the parity and body mass index.
The serum level of the placental growth factor seems to be a promising biomarker for diagnosing ectopic pregnancy because a highly significant difference was found between healthy and ectopic pregnancy.
异位妊娠是妇科极为重要的病症。当受精卵在子宫腔外着床时就会发生异位妊娠。据估计，异位妊娠占所有自然受孕的1 - 2%。本研究旨在评估胎盘生长因子在异位妊娠诊断中的作用。
在伊拉克巴格达的教学医院进行了为期一年的病例对照研究。该研究纳入240名女性：120名孕早期（5 - 10周）宫内活胎妊娠女性，以及120名异位妊娠女性。
观察到胎盘生长因子均值（PLGF）存在显著关联，异位妊娠中的PLGF低于宫内妊娠。异位妊娠中PLGF范围小于50 pg/mL，而宫内妊娠中可达800 pg/mL。在截断PLGF水平≤15.5 pg/mL的异位妊娠中，PLGF的敏感性为（92.5%），特异性为（82.5%），阳性预测值为（91.8%），阴性预测值为（83.5%），准确性为（90%）。不同因素会影响PLGF，如产次和体重指数。
胎盘生长因子的血清水平似乎是诊断异位妊娠的一个有前景的生物标志物，因为在正常妊娠和异位妊娠之间发现了高度显著的差异。
