School of Psychology, UNSW Sydney, Sydney, NSW, Australia.
J Neurochem. 2021 Jun;157(5):1572-1584. doi: 10.1111/jnc.15309. Epub 2021 Feb 10.
The actions of dopamine are essential to relapse to drug seeking but we still lack a precise understanding of how dopamine achieves these effects. Here we review recent advances from animal models in understanding how dopamine controls relapse to drug seeking. These advances have been enabled by important developments in understanding the basic neurochemical, molecular, anatomical, physiological and functional properties of the major dopamine pathways in the mammalian brain. The literature shows that although different forms of relapse to seeking different drugs of abuse each depend on dopamine, there are distinct dopamine mechanisms for relapse. Different circuit-level mechanisms, different populations of dopamine neurons and different activity profiles within these dopamine neurons, are important for driving different forms of relapse. This diversity highlights the need to better understand when, where and how dopamine contributes to relapse behaviours.
多巴胺的作用对于药物寻求的复燃至关重要，但我们仍然缺乏对多巴胺如何产生这些影响的确切理解。在这里，我们回顾了动物模型在理解多巴胺如何控制药物寻求复燃方面的最新进展。这些进展得益于对哺乳动物大脑中主要多巴胺通路的基本神经化学、分子、解剖、生理和功能特性的重要理解。文献表明，尽管不同形式的复吸不同的滥用药物都依赖于多巴胺，但复吸的多巴胺机制是不同的。不同的回路水平机制、不同的多巴胺神经元群体以及这些多巴胺神经元内的不同活动模式，对于驱动不同形式的复吸都很重要。这种多样性突出表明需要更好地理解多巴胺何时、何地以及如何参与复吸行为。
