中国儿童和青少年睡眠时间短与超重或肥胖发病率的关系：一项前瞻性研究的系统评价和荟萃分析。

Short duration of sleep and incidence of overweight or obesity in Chinese children and adolescents: A systematic review and meta-analysis of prospective studies.

机构信息

University of Warwick, Warwick Medical School, Division of Health Sciences (Mental Health & Wellbeing), Gibbet Hill Road, Coventry, CV4 7AL, UK.

University of Warwick, Warwick Medical School, Division of Health Sciences (Mental Health & Wellbeing), Gibbet Hill Road, Coventry, CV4 7AL, UK; University Hospital Coventry & Warwickshire NHS Trust, Clifford Bridge Road, Coventry, CV2 2DX, UK.

出版信息

Nutr Metab Cardiovasc Dis. 2021 Feb 8;31(2):363-371. doi: 10.1016/j.numecd.2020.11.001. Epub 2020 Nov 11.

DOI:10.1016/j.numecd.2020.11.001

PMID:33487495

Abstract

BACKGROUND AND AIMS

Overweight and obesity in children have become a global public health problem. Epidemiological studies suggest that sleep duration may contribute to the incidence of overweight and obesity in all stages of life. China has an increasing prevalence of overweight and obesity, and sleep deprivation is common among Chinese children. The aim of this study was to assess the prospective relationship between short sleep duration and overweight or obesity in Chinese children and to gain an estimate of the risk.

METHODS AND RESULTS

A systematic search was performed on 28/04/2020 by using Medline, PubMed and Web of Science. The exposure was the duration of sleep, and the outcome measure the incidence of overweight or obesity. The odds ratios (OR) and hazard ratios (HR) and 95% confidence intervals (C.I.) were extracted to calculate the pooled relative risk (RR) by a random effect model. Heterogeneity and publication bias of the studies were checked by sensitivity analysis. Seven studies fulfilled the criteria for a systematic review, and 5 studies for a meta-analysis. The total of 33,206 participants included boys and girls, aged 6-17 years old. In Chinese children the pooled RR for short sleep duration and overweight or obesity combined was 1.47 (95% C.I. 1.26, 1.71, p < 0.00001, n = 32,607), and for obesity alone 1.40 (95% C.I. 1.01, 1.95, p = 0.04, n = 17,038). There was no significant heterogeneity or publication bias between studies.

CONCLUSION

Short sleep duration is associated with the development of overweight and obesity in Chinese children.

摘要

背景和目的

儿童超重和肥胖已成为全球性公共卫生问题。流行病学研究表明，睡眠时长可能与一生中超重和肥胖的发生有关。中国超重和肥胖的患病率不断增加，儿童睡眠不足也较为常见。本研究旨在评估中国儿童短睡眠时长与超重或肥胖的前瞻性关系，并估计其风险。

方法和结果

我们于 2020 年 4 月 28 日通过 Medline、PubMed 和 Web of Science 进行了系统检索。暴露因素为睡眠时间，结局指标为超重或肥胖的发生率。采用随机效应模型提取比值比（OR）和风险比（HR）及其 95%置信区间（CI），以计算汇总相对风险（RR）。通过敏感性分析检查研究的异质性和发表偏倚。有 7 项研究符合系统评价标准，5 项研究符合荟萃分析标准。共有 33206 名参与者，包括男孩和女孩，年龄为 6-17 岁。在中国儿童中，短睡眠时长与超重或肥胖合并的汇总 RR 为 1.47（95%CI 1.26, 1.71，p<0.00001，n=32607），肥胖的 RR 为 1.40（95%CI 1.01, 1.95，p=0.04，n=17038）。研究之间无显著异质性或发表偏倚。