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口服普萘洛尔治疗溃疡性出血性阴囊动静脉畸形

Oral Propranolol in the Treatment of Ulcerated Bleeding Scrotal Arteriovenous Malformation.

作者信息

Singh Gurmeet, Gupta Archika, Gupta Sarvesh Kumar, Rai Rahul Kumar, Pandey Anand, Kureel S N

机构信息

Department of Pediatric Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.

出版信息

J Indian Assoc Pediatr Surg. 2020 Nov-Dec;25(6):401-403. doi: 10.4103/jiaps.JIAPS_232_19. Epub 2020 Oct 27.

DOI:10.4103/jiaps.JIAPS_232_19
PMID:33487946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7815032/
Abstract

Arteriovenous malformations (AVMs) of the scrotum are very rare, with only 35 adult cases in the literature. An 8-year-old boy presented with an ulcerated bleeding AVM of the scrotum. The patient was resuscitated and managed conservatively initially. After the control of bleeding, oral propranolol was started. There was a decrease in the size of scrotal and penile swelling, healing of ulcer with total healing by 1 month, and no recurrence of bleeding episode. To the best of our knowledge, this was the first case of pediatric scrotal AVM treated by oral propranolol.

摘要

阴囊动静脉畸形(AVM)非常罕见,文献中仅有35例成人病例。一名8岁男孩出现阴囊溃疡性出血性AVM。患者最初接受复苏并进行保守治疗。出血得到控制后,开始口服普萘洛尔。阴囊和阴茎肿胀的大小减小,溃疡愈合,1个月时完全愈合,且未再发生出血事件。据我们所知,这是首例口服普萘洛尔治疗的小儿阴囊AVM病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ef9/7815032/6e1a5b28017e/JIAPS-25-401-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ef9/7815032/097ba4a068f0/JIAPS-25-401-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ef9/7815032/6e1a5b28017e/JIAPS-25-401-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ef9/7815032/097ba4a068f0/JIAPS-25-401-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ef9/7815032/6e1a5b28017e/JIAPS-25-401-g002.jpg

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本文引用的文献

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Propranolol as a potentially novel treatment of arteriovenous malformations.普萘洛尔作为一种治疗动静脉畸形的潜在新疗法。
JAAD Case Rep. 2018 Apr 4;4(4):355-358. doi: 10.1016/j.jdcr.2017.11.005. eCollection 2018 May.
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Propranolol Treatment of Vascular Anomalies Other Than Infantile Hemangioma.普萘洛尔治疗除婴儿血管瘤以外的血管异常。
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Dermatoendocrinol. 2015 Jan 26;6(1):e979699. doi: 10.4161/19381980.2014.979699. eCollection 2014 Jan-Dec.
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Management of infantile hemangiomas: current trends.婴儿血管瘤的管理:当前趋势
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Successful treatment of a congenital extra-truncal vascular malformation by orally administered propranolol.口服普萘洛尔成功治疗先天性躯干外血管畸形
J Dermatolog Treat. 2015 Feb;26(1):59-62. doi: 10.3109/09546634.2013.869301. Epub 2013 Dec 20.
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Bleeding scrotal vascular lesions: interventional management with transcatheter embolization.阴囊血管性病变出血:经导管栓塞的介入治疗管理。
Cardiovasc Intervent Radiol. 2011 Feb;34 Suppl 2:S113-6. doi: 10.1007/s00270-010-0007-8. Epub 2010 Nov 5.
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Bleeding scrotal arteriovenous malformation.阴囊动静脉畸形出血
J Emerg Med. 2012 Jun;42(6):e133-5. doi: 10.1016/j.jemermed.2009.05.026. Epub 2009 Aug 13.
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Recurrent scrotal arteriovenous malformation.
J Urol. 2004 Apr;171(4):1628. doi: 10.1097/01.ju.0000121603.27901.d2.
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Scrotal arteriovenous malformation and its preoperative embolization.阴囊动静脉畸形及其术前栓塞
Eur Radiol. 1999;9(3):425-7. doi: 10.1007/s003300050686.