Kresnoadi Utari, Lunardhi Louisa Christy, Agustono Bambang
Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
J Indian Prosthodont Soc. 2020 Oct-Dec;20(4):417-423. doi: 10.4103/jips.jips_106_20. Epub 2020 Oct 8.
To determine the potential of propolis extract and BBG combination on the quantity of fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor (VEGF), and osteoblasts in the preservation of tooth extraction socket on days 3 and 7.
Laboratory in vivo reseach using animal model.
Fifty-six Cavia cobaya were divided into eight groups containing seven animals in each group. The extraction socket on the lower left incisor was filled with polyethylene glycol (PEG) at a concentration of 2% (Groups I and II) as a control; active materials consisted of propolis extract and PEG (Groups III and IV); active materials consisted of BBG and PEG (Groups V and VI); and active materials consisted of propolis extract, BBG, and PEG (Groups VII and VIII). Then, an examination was done using immunohistochemistry to perform an expression of VEGF, FGF2, as well as histology of osteoblasts.
The statistical analysis performed using a one-way ANOVA and Tukey's honestly significant difference test.
Propolis extract, BBG and PEG had the most significant result related to the formation of FGF2, VEGF, and osteoblasts.
The combination of propolis extract with BBG and PEG in socket preservation is effective in increasing the expression of FGF2, VEGF, and osteoblasts.
确定蜂胶提取物与BBG联合使用对拔牙窝在第3天和第7天时成纤维细胞生长因子2（FGF - 2）、血管内皮生长因子（VEGF）数量以及成骨细胞的影响。
采用动物模型的体内实验室研究。
56只豚鼠被分为8组，每组7只。左下切牙的拔牙窝用浓度为2%的聚乙二醇（PEG）填充作为对照（第I组和第II组）；活性材料由蜂胶提取物和PEG组成（第III组和第IV组）；活性材料由BBG和PEG组成（第V组和第VI组）；活性材料由蜂胶提取物、BBG和PEG组成（第VII组和第VIII组）。然后，采用免疫组织化学方法检测VEGF、FGF2的表达以及成骨细胞的组织学情况。
采用单因素方差分析和Tukey真实显著性差异检验进行统计分析。
蜂胶提取物、BBG和PEG在FGF2、VEGF和成骨细胞形成方面的效果最为显著。
蜂胶提取物与BBG和PEG联合用于拔牙窝保存可有效增加FGF2、VEGF和成骨细胞的表达。
