Boniface R J, Cain P R, Evans C H
Ferguson Laboratory for Orthopaedic Research, School of Medicine, University of Pittsburgh, Pennsylvania 15261.
Arthritis Rheum. 1988 Feb;31(2):258-66. doi: 10.1002/art.1780310214.
To examine whether proteoglycans (PGs) liberated from cartilage might contribute to articular changes in arthritis, cartilage PGs were injected intraarticularly into rabbit knee joints. Twice-weekly injections of PG (2.5 mg) provoked synovial hypertrophy, synovitis, erosion of the articulating surfaces, and loss of metachromasia of the articular cartilage. These changes were accompanied by a marked elevation in the production of neutral collagenase and gelatinase by both synoviocytes and chondrocytes. The synoviocytes of experimental knee joints also produced factor(s), possibly related to interleukin-1, which provoked the activation of chondrocytes. Our data are consistent with the idea that free PG fragments mediate some of the pathophysiologic changes that occur in arthritic joints. This property may be particularly important in osteoarthritis.
为了研究从软骨中释放出的蛋白聚糖（PGs）是否可能导致关节炎中的关节变化，将软骨PGs关节内注射到兔膝关节中。每周两次注射PG（2.5毫克）引发滑膜肥大、滑膜炎、关节表面侵蚀以及关节软骨异染性丧失。这些变化伴随着滑膜细胞和软骨细胞产生的中性胶原酶和明胶酶显著升高。实验性膝关节的滑膜细胞还产生了可能与白细胞介素-1相关的因子，该因子引发软骨细胞的活化。我们的数据与游离PG片段介导关节炎关节中发生的一些病理生理变化的观点一致。这种特性在骨关节炎中可能尤为重要。
