PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing.

To evaluate the mycophenolic acid [MPA, the active form of mycophenolate mofetil (MMF)] pharmacokinetic parameters in relation to clinical response to identify target exposure ranges in pediatric patients with systemic lupus erythematosus (SLE). This was a retrospective study using pharmacokinetic data collected in 67 pediatric patients aged 4-18 years with SLE. Target MPA exposures for effective inhibition of SLE activity (as measured by SLE disease Activity Index (SLEDAI), active SLE was defined as a SLEDAI score of ≥6, and a controlled disease was defined as a SLEDAI score of ≤4) were assessed by receiver operating characteristic (ROC) curve and logistic regression. Exposure-response models were developed to quantitatively describe the relationship between SLEDAI score and AUC or C, respectively. The MPA AUC in patients with active SLE was significantly lower than that in patients with inactive SLE. ROC analysis revealed that an AUC threshold of 39 μg h/ml or a C of 1.01 μg/ml was associated with the lowest risk of active SLE. Logistic regression analysis revealed that an AUC of less than 34 μg h/ml or a C of less than 1.2 μg/ml probably is associated with active SLE. The results of the exposure-response modeling also indicated that an AUC less than 32 μg h/ml or a C less than 1.1 μg/ml was associated with suboptimal clinical outcome. An AUC above 50 μg h/ml or a C above 1.7 ug/ml was associated with disease control. Both AUC and C of MPA are predictive of the likelihood of active SLE in pediatric patients receiving MMF. An individualized dosing regimen of MMF, with a target AUC or C, should be considered for SLE patients.