Lu Zengbing, Zhou Yu, Tu Longlong, Chan Sze Wa, Ngan Man P, Cui Dexuan, Liu Yuen Hang Julia, Huang Ianto Bosheng, Kung Jeng S C, Hui Chung Man Jessica, Rudd John A
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
School of Health Sciences, Caritas Institute of Higher Education, Tseung Kwan O New Town, Hong Kong.
Front Physiol. 2021 Jan 8;11:583082. doi: 10.3389/fphys.2020.583082. eCollection 2020.
Nausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical techniques can determine the relative degrees of brady-, normo-, and tachygastric power, but lose information relative to the basic slow wave shape. The aim of the present study was to investigate the application of advanced analytical techniques in the analysis of disrupted GMA recorded after administration of sulprostone, a prostaglandin E agonist, in ferrets. Ferrets were implanted with radiotelemetry devices to record GMA, blood pressure, heart rate (HR) and core body temperature 1 week before the administration of sulprostone (30 μg/kg) or vehicle (saline, 0.5 mL/kg). GMA was initially analyzed using fast Fourier transformations (FFTs) and a conventional power partitioning. Detrended fluctuation analysis (DFA) was also applied to the GMA recordings to reveal information relative to the fluctuation of signals around local trends. Sample entropy (SampEn) analysis was used for examining the regularity of signals. Conventional signal processing techniques revealed that sulprostone increased the dominant frequency (DF) of slow waves, with an increase in the percentage power of the tachygastric range and a decrease in the percentage power of the normogastric range. DFA revealed that sulprostone decreased the fluctuation function, indicative of a loss of the variability of GMA fluctuations around local trends. Sulprostone increased SampEn values, indicating a loss of regularity in the GMA data. Behaviorally, sulprostone induced emesis and caused defecation. It also increased blood pressure and elevated HR, with an associated decrease in HR variability (HRV). Further analysis of HRV revealed a decrease in both low-frequency (LF) and high-frequency (HF) components, with an overall increase in the LF/HF ratio. Sulprostone did not affect core body temperature. In conclusion, DFA and SampEn permit a detailed analysis of GMA, which is necessary to understand the action of sulprostone to modulate gastric function. The action to decrease HRV and increase the LF/HF ratio may be consistent with a shift toward sympathetic nervous system dominance, commonly seen during nausea.
疾病或药物治疗引起的恶心和呕吐可能与胃肌电活动（GMA）紊乱有关。传统分析技术可以确定胃动过缓、正常胃动和胃动过速的相对程度，但会丢失与基本慢波形状相关的信息。本研究的目的是探讨先进分析技术在分析雪貂注射前列腺素E激动剂硫前列酮后记录的GMA紊乱中的应用。在注射硫前列酮（30μg/kg）或赋形剂（生理盐水，0.5mL/kg）前1周，给雪貂植入无线电遥测装置以记录GMA、血压、心率（HR）和核心体温。GMA最初使用快速傅里叶变换（FFT）和传统功率划分进行分析。去趋势波动分析（DFA）也应用于GMA记录，以揭示与局部趋势周围信号波动相关的信息。样本熵（SampEn）分析用于检查信号的规律性。传统信号处理技术显示，硫前列酮增加了慢波的主导频率（DF），心动过速范围的功率百分比增加，正常胃动范围的功率百分比降低。DFA显示，硫前列酮降低了波动函数，表明GMA在局部趋势周围波动的变异性丧失。硫前列酮增加了SampEn值，表明GMA数据规律性丧失。行为上，硫前列酮引起呕吐和排便。它还增加了血压，提高了心率，并伴有心率变异性（HRV）降低。对HRV的进一步分析显示，低频（LF）和高频（HF）成分均降低，LF/HF比值总体增加。硫前列酮不影响核心体温。总之，DFA和SampEn允许对GMA进行详细分析，这对于理解硫前列酮调节胃功能的作用是必要的。降低HRV和增加LF/HF比值的作用可能与向交感神经系统优势的转变一致，这在恶心期间很常见。
