Unit of Blood Disease and Stem Cell Transplantation, Chair of Hematology, University of Brescia, ASST Spedali Civili, Brescia, Italy.
University of Brescia, Brescia, Italy.
Front Immunol. 2021 Jan 6;11:535890. doi: 10.3389/fimmu.2020.535890. eCollection 2020.
Malnutrition is a common problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and could impair immune function. Immune dysfunction after allo-HSCT may be linked with infections, GVHD, and relapse and negatively affect the outcome. Aim of this review was to identify malnutrition biomarkers, potentially useful for immune-system monitoring, in the setting of allo-HSCT. After a systematic search, no satisfying biomarker was found, except for citrulline. Citrulline could be useful in monitoring gastrointestinal function after allo-HSCT and its role in the complex relationship with immune-system function ought to be better explored. A multi-omics approach, including biomarkers and PRO (patient reported outcomes) is, in our opinion, the optimal way to study the relationship between malnutrition and transplant outcomes.
营养不良是异基因造血干细胞移植（allo-HSCT）后的常见问题，可能会损害免疫功能。allo-HSCT 后免疫功能障碍可能与感染、GVHD 和复发有关，并对预后产生负面影响。本综述的目的是确定 allo-HSCT 中用于免疫系统监测的潜在有用的营养不良生物标志物。经过系统搜索，除了瓜氨酸外，没有发现令人满意的生物标志物。瓜氨酸可用于监测 allo-HSCT 后的胃肠道功能，其在与免疫系统功能的复杂关系中的作用应进一步探讨。我们认为，包括生物标志物和 PRO（患者报告结果）在内的多组学方法是研究营养不良与移植结果之间关系的最佳方法。
