Song Seung-Eun, Kim Dong Hyeok, Kim Seong-Han, Park Mi-Sun, Park Sang-Hee, Lee Kil-Soo
Division of Bacterial Disease, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju-si, Chungcheongbuk-Do 28159, Republic of Korea.
Division of Bacterial Disease Research, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju-si, Chungcheongbuk-Do 28159, Republic of Korea.
Can J Infect Dis Med Microbiol. 2020 Dec 31;2020:8874309. doi: 10.1155/2020/8874309. eCollection 2020.
Tuberculosis (TB) is an ongoing global health problem, including in South Korea. To manage TB efficiently, it is necessary to understand the epidemiology, transmission route, and characteristics of prevailing strains. In this study, we investigated microevolutions over time in the spoligotype patterns of isolated from TB patients in Korea. We collected 1,055 clinical isolates from 16 provinces in Korea from 1994 to 2006 and analyzed them by spoligotyping. We observed 26 subfamilies, including two large predominant families: a Beijing family (72.7%) and the T family (19.1%). Specifically, the abundance of spoligotype SIT269 from the Beijing-like subfamily significantly increased in the 2000s relative to the 1990s in Korea. This study provides an overview of the genotype trends over time in Korea. These data also indicate that we should consider the influence of the newly growing SIT269 subtype identified in the Beijing family.
结核病（TB）仍是一个全球性的健康问题，在韩国也不例外。为了有效地管理结核病，有必要了解其流行病学、传播途径以及流行菌株的特征。在本研究中，我们调查了韩国结核病患者分离株的间隔寡核苷酸分型（spoligotype）模式随时间的微观进化情况。我们收集了1994年至2006年期间来自韩国16个省份的1055份临床分离株，并通过间隔寡核苷酸分型进行分析。我们观察到26个亚家族，包括两个主要的大家族：北京家族（72.7%）和T家族（19.1%）。具体而言，与20世纪90年代相比，21世纪初韩国类似北京亚家族的间隔寡核苷酸分型SIT269的丰度显著增加。本研究概述了韩国随时间变化的基因型趋势。这些数据还表明，我们应该考虑在北京家族中新出现的SIT269亚型的影响。
