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一名获得性凝血因子V抑制剂导致一名术后患者出现无法控制的出血。

An acquired factor V inhibitor induced uncontrolled bleeding in a postsurgery patient.

作者信息

Bruna Riccardo, Moia Riccardo, Valpreda Alessandra, Dosio Enrico, Rolla Roberta, Federici Augusto, Dianzani Umberto, Gaidano Gianluca, Patriarca Andrea

机构信息

Division of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara Italy.

Regional Center for Hemorrhagic and Thrombotic Diseases Haematology Laboratory City of Health and Science University Hospital of Molinette Turin Italy.

出版信息

Clin Case Rep. 2020 Dec 1;9(1):98-101. doi: 10.1002/ccr3.3452. eCollection 2021 Jan.

DOI:10.1002/ccr3.3452
PMID:33489140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7813060/
Abstract

This case report highlights the challenges in controlling bleeding and correcting coagulation tests through the use of bypassing agents in patients with FV inhibitors.

摘要

本病例报告强调了在FV抑制剂患者中使用旁路制剂控制出血和纠正凝血试验方面所面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9456/7813060/a06d75488a4d/CCR3-9-98-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9456/7813060/a06d75488a4d/CCR3-9-98-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9456/7813060/a06d75488a4d/CCR3-9-98-g001.jpg

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本文引用的文献

1
A very potent factor V inhibitor interferes with the levels of all coagulation factors and causes a fatal hemorrhagic syndrome.一种非常有效的因子 V 抑制剂会干扰所有凝血因子的水平，导致致命性出血综合征。
Eur J Haematol. 2019 Aug;103(2):137-139. doi: 10.1111/ejh.13249. Epub 2019 May 28.
2
Inherited and acquired factor V deficiency.遗传性和获得性因子V缺乏症。
Blood Coagul Fibrinolysis. 2011 Apr;22(3):160-6. doi: 10.1097/MBC.0b013e3283424883.
3
Acquired factor V inhibitors: a systematic review.获得性因子 V 抑制剂：系统评价。
J Thromb Thrombolysis. 2011 May;31(4):449-57. doi: 10.1007/s11239-010-0529-6.
4
Acquired factor V inhibitor. A problem-based systematic review.获得性凝血因子V抑制剂。基于问题的系统评价。
Thromb Haemost. 2009 May;101(5):852-9.
5
Anti-factor V auto-antibody in the plasma and platelets of a patient with repeated gastrointestinal bleeding.一名反复出现胃肠道出血患者血浆及血小板中的抗凝血因子V自身抗体
J Thromb Haemost. 2003 May;1(5):943-9. doi: 10.1046/j.1538-7836.2003.00143.x.
6
Fibrin glue in surgery: frequent development of inhibitors of bovine thrombin and human factor V.手术中使用的纤维蛋白胶：牛凝血酶和人因子V抑制剂的频繁产生。
Br J Haematol. 1993 Nov;85(3):528-32. doi: 10.1111/j.1365-2141.1993.tb03343.x.