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一名患有镰状细胞病的青少年出现血小板增多症并伴有获得性血管性血友病。

Thrombocytosis with acquired von Willebrand disease in an adolescent with sickle cell disease.

作者信息

Yee Marianne E M, Batsuli Glaivy, Chonat Satheesh, Park Sunita

机构信息

Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta GA USA.

Department of Pediatrics Division of Hematology/Oncology Emory University School of Medicine Atlanta GA USA.

出版信息

Clin Case Rep. 2020 Nov 20;9(1):457-460. doi: 10.1002/ccr3.3556. eCollection 2021 Jan.

DOI:10.1002/ccr3.3556
PMID:33489197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7813102/
Abstract

Thrombocytosis is common in sickle cell disease and may contribute to vaso-occlusion. Hydroxyurea treats extreme thrombocytosis. Acquired von Willebrand disease should be considered prior to aspirin therapy.

摘要

血小板增多症在镰状细胞病中很常见，可能会导致血管阻塞。羟基脲可治疗极度血小板增多症。在使用阿司匹林治疗前应考虑获得性血管性血友病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d762/7813102/59c513970f07/CCR3-9-457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d762/7813102/59c513970f07/CCR3-9-457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d762/7813102/59c513970f07/CCR3-9-457-g001.jpg

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本文引用的文献

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Genetic analysis of five children with essential thrombocytosis identified mutations in cancer-associated genes with roles in transcriptional regulation.对五名原发性血小板增多症患儿的基因分析发现，在转录调控中起作用的癌症相关基因发生了突变。
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