Lim Darosa, Belisle Annie, Davar Sandra
Division of Dermatology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
Department of Pathology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
SAGE Open Med Case Rep. 2020 Dec 25;8:2050313X20984121. doi: 10.1177/2050313X20984121. eCollection 2020.
Hailey-Hailey disease is a rare autosomal dominant acantholytic disorder due to mutation in the gene and presents with flaccid blisters in intertriginous regions. Its chronic and relapsing course may negatively impact patients' quality of life. Multiple medical and interventional treatments have been described with various efficacy. Low-dose naltrexone and oral magnesium chloride represent emerging treatments. Sustained improvement in Hailey-Hailey disease has been reported with the former in case series, while others have shown variable results. Oral magnesium chloride has been reported in four patients with possible results after 2-4 weeks. Two recent cases suggest that the combination of both treatments may have a synergistic effect. Herein, we present a 63-year-old woman with long-standing and recurrent bilateral inguinal Hailey-Hailey disease who significantly improved with low-dose naltrexone and oral magnesium chloride, representing the third case described with this combination.
黑利-黑利病是一种罕见的常染色体显性棘层松解性疾病，由该基因的突变引起，表现为皮肤褶皱部位的松弛水疱。其慢性复发性病程可能会对患者的生活质量产生负面影响。已经描述了多种药物和介入治疗方法，疗效各异。低剂量纳曲酮和口服氯化镁是新兴的治疗方法。在病例系列中，已有报道称前者可使黑利-黑利病持续改善，而其他治疗方法的效果则各不相同。有报道称，4例患者口服氯化镁，2 - 4周后可能出现疗效。最近的2例病例表明，两种治疗方法联合使用可能具有协同作用。在此，我们报告1例63岁女性，患有长期复发性双侧腹股沟黑利-黑利病，采用低剂量纳曲酮和口服氯化镁治疗后病情显著改善，这是第三例采用该联合治疗方法的病例。
