多发性骨髓瘤患者骨髓移植10年后发生隐球菌性脑膜脑炎。

Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma.

作者信息

Stepman Gauthier, Sanapati Jaya, Dabb Kulveer, Angelo Debra, Frunzi Johnathan

机构信息

Internal Medicine, Medical Center of Trinity, Trinity, USA.

出版信息

Cureus. 2020 Dec 15;12(12):e12094. doi: 10.7759/cureus.12094.

DOI:10.7759/cureus.12094

PMID:33489511

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7805512/

Abstract

Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.

摘要

隐球菌病是一种真菌感染，主要影响免疫功能低下的患者。诊断基于脑脊液（CSF）或血清中隐球菌抗原的检测。抗真菌耐药性正在出现，使得治疗困难且疗程漫长。我们报告一例多发性骨髓瘤患者在接受骨髓移植数年之后发生隐球菌病的病例。症状较轻，影像学检查无特异性。脑脊液分析显示隐球菌抗原阳性。该患者开始接受标准的三相抗真菌治疗并康复。