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首例因出血性膀胱炎接受持续膀胱冲洗的患者发生高氯性非阴离子间隙代谢性酸中毒的报告

First Reported Case of Hyperchloremic Non-Anion Gap Metabolic Acidosis in a Patient Undergoing Continuous Bladder Irrigation for Hemorrhagic Cystitis.

作者信息

Latif Azka, Thirumalareddy Joseph, Sood Akshat, Nair Sunil, Tauseef Abubakar

机构信息

Internal Medicine, CHI Creighton University, Omaha, USA.

Hospital Medicine, Creighton University School of Medicine, St. Joseph's Hospital and Medical Center, Omaha, USA.

出版信息

Cureus. 2020 Dec 17;12(12):e12132. doi: 10.7759/cureus.12132.

DOI:10.7759/cureus.12132
PMID:33489544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7813527/
Abstract

Radiation cystitis can present as gross hematuria and occurs secondary to irritation of the bladder urothelium. Continuous bladder irrigation (CBI) is commonly used for the treatment of hemorrhagic cystitis for evacuation of blood clots and to maintain catheter drainage. Most commonly, CBI is performed using 0.9% sodium chloride. We report a 77-year-old female who developed hyperchloremic non-anion gap metabolic acidosis (H-NAGMA) and pulmonary edema secondary to absorption of 0.9% normal saline (NS) from CBI. In such cases, ringer lactate with low concentration (109 mEq) of chloride as compared to NS (154 mEq) can prove to be a suitable alternative.

摘要

放射性膀胱炎可表现为肉眼血尿,继发于膀胱尿路上皮受到刺激。持续膀胱冲洗(CBI)常用于治疗出血性膀胱炎,以清除血凝块并维持导尿管引流。最常用的是使用0.9%氯化钠进行持续膀胱冲洗。我们报告了一名77岁女性,她因持续膀胱冲洗吸收0.9%生理盐水(NS)继发高氯性非阴离子间隙代谢性酸中毒(H-NAGMA)和肺水肿。在这种情况下,与生理盐水(154 mEq)相比,含低浓度(109 mEq)氯化物的乳酸林格液可能是一种合适的替代选择。

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本文引用的文献

1
Bladder irrigation and urothelium disruption: a reminder apropos of a case of fatal fluid absorption.膀胱冲洗与尿路上皮破坏:关于一例致命性液体吸收病例的提示
BMC Urol. 2014 Nov 20;14:91. doi: 10.1186/1471-2490-14-91.
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Intravesical drug delivery: Challenges, current status, opportunities and novel strategies.膀胱内药物递送:挑战、现状、机遇与新策略。
J Control Release. 2010 Dec 1;148(2):147-59. doi: 10.1016/j.jconrel.2010.08.031. Epub 2010 Sep 8.
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Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review.高压氧疗法治疗正常组织放射性损伤的文献综述
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Everything you wanted to know about the bladder epithelium but were afraid to ask.关于膀胱上皮你想知道却不敢问的一切。
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Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC).放射治疗肿瘤学组(RTOG)和欧洲癌症研究与治疗组织(EORTC)的毒性标准。
Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1341-6. doi: 10.1016/0360-3016(95)00060-C.
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Bladder irrigation or irritation?膀胱冲洗还是刺激?
Br J Urol. 1989 Oct;64(4):391-4. doi: 10.1111/j.1464-410x.1989.tb06049.x.